Table III.
Regions of grey matter atrophy in PPMS and SPMS patients vs. healthy controls, and between SPMS vs. PPMS patients (small‐volume corrected P‐values)
| Anatomical region | PPMS vs. healthy controls | SPMS vs. healthy controls | SPMS vs. PPMS | ||||||
|---|---|---|---|---|---|---|---|---|---|
| MNI space coordinates | t value | P value | MNI space coordinates | t value | P value | MNI space coordinates | t value | P value | |
| Thalamus | |||||||||
| L | −14, −16, 10 | 3.3 | 0.05 | −14, −8, −8 | 7.1 | <0.001 | −10, −22, −2 | 6.5 | <0.001 |
| R | — | — | — | 12, −10, −4 | 6.1 | <0.001 | 12, −14, −4 | 5.9 | <0.001 |
| Pallidus | |||||||||
| L | 20, −6, −6 | 3.8 | 0.01 | — | — | — | – | — | — |
| R | — | — | — | — | — | — | – | — | — |
| Putamen | |||||||||
| L | — | — | — | −24, 6, −4 | 4.6 | 0.002 | −22, 8, 10 | 4.1 | 0.006 |
| R | — | — | — | 24, 4, −4 | 4.8 | 0.001 | 28, 2, −2 | 3.9 | 0.01 |
| Precentral gyrus (BA4) | |||||||||
| L | −24, −28, 64 | 3.6 | 0.02 | — | — | — | — | — | — |
| R | — | — | — | 46, −18, 48 | 4.1 | 0.007 | — | — | — |
| Premotor cortex (BA6) | |||||||||
| L | — | — | — | −38, 0, 44 | 3.6 | 0.02 | −42, −2, 62 | 3.5 | 0.02 |
| −8, −6, 72 | 4.2 | 0.01 | |||||||
| R | 8, −10, 58 | 3.8 | 0.01 | 38, 14, 50 | 4.8 | 0.001 | — | — | — |
| Postcentral gyrus (BA3) | |||||||||
| L | — | — | — | −40, −24, 46 | 4.5 | 0.003 | −40, −24, 56 | 3.9 | 0.01 |
| −38, −32, 50 | 3.3 | 0.03 | |||||||
| R | — | — | — | 50, −16, 54 | 3.9 | 0.01 | — | — | — |
| Paracentral lobule (BA6) | |||||||||
| L | — | — | — | −2, −34, 56 | 4.4 | 0.003 | −4, −34, 56 | 4.1 | 0.007 |
| SFG (BA8) | |||||||||
| L | — | — | — | −22, 12, 52 | 5.0 | 0.001 | −26, 20, 56 | 3.8 | 0.005 |
| Insula | |||||||||
| L | −36, 30, 0 | 3.5 | 0.02 | −34, 26, 6 | 3.5 | 0.03 | — | — | — |
| Dorsal ACC (BA32) | |||||||||
| R | — | — | — | 0, 14, 46 | 3.9 | 0.01 | — | — | — |
| Dorsal PCC | |||||||||
| (BA31) | |||||||||
| R | — | — | — | 14, −42, 34 | 3.8 | 0.01 | — | — | — |
| Cerebellum (lobule VI) | |||||||||
| L | — | — | — | −22, −74, −18 | 4.2 | 0.005 | — | — | — |
| R | 26, −64, −28 | 3.3 | 0.04 | 28, −64, −26 | 3.3 | 0.04 | — | — | — |
Abbreviations: PPMS = primary progressive multiple sclerosis; SPMS = secondary progressive multiple sclerosis; L = left; R = right; BA = Brodmann area; SFG = superior frontal gyrus; ACC = anterior cingulate cortex; PCC = posterior cingulate cortex.