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. 2011 Apr 11;32(5):800–811. doi: 10.1002/hbm.21067

Figure 3.

Figure 3

Functional connectivity between the left NAcc and other areas during reward anticipation. (A) For both reward (RC) and no‐reward cues (NRC), the NAcc showed more connections with the prefrontal cortex (PFC) under placebo (Plb) but more connections with the insula under pramipexole (Prm). (B) The NAcc‐connectivity was stronger under pramipexole than under placebo (Prm > Plb) in the Insula. The NAcc‐connectivity was stronger under placebo than under pramipexole (Plb > Prm) in prefrontal regions such as the medial superior frontal gyrus/anterior cingulate cortex (mSFG/ACC), supplementary motor area/middle cingulate cortex (SMA/MCC), medial orbitofrontal cortex (mOFC), superior frontal gyrus (SFG), and inferior frontal gyrus (IFG). There was no significant difference in functional connectivity between reward and no‐reward cues (neither for RC > NRC nor for NRC > RC). Color scale indicates t values. Coordinates in MNI; L, left; R, right. (C) Normalized correlation coefficients (r) in the mSFG and the right insula during reward anticipation under placebo (black) and pramipexole (white). Bars show means and error bars indicate standard errors.