Table III.
Mean GM density of hippocampi, precuneus, and anterior cingulate gyrus, and mean FA and MD of the cingulum bundle
| HS | a‐MCI patients | AD patients | |
|---|---|---|---|
| GM density of the left hippocampal/ parahippocampal areas MNI coord: (−22, −12, −16) | 0.53 ± 0.05 | 0.50 ± 0.06 | 0.42 ± 0.08 |
| GM density of the right hippocampal/ parahippocampal areas MNI coord: (16, −10, −16) | 0.50 ± 0.05 | 0.47 ± 0.05 | 0.40 ± 0.07 |
| GM density of the precuneus MNI coord: (0, −54, 40) | 0.49 ± 0.08 | 0.49 ± 0.08 | 0.38 ± 0.05 |
| GM density of the ACC/SFG MNI coord: (−2, 52, −8) | 0.40 ± 0.08 | 0.38 ± 0.05 | 0.31 ± 0.06 |
| FA of cinguli | 0.26 ± 0.02 | 0.24 ± 0.02 | 0.23 ± 0.02 |
| MD of cinguli mm2 s−1 × 10−3 | 0.96 ± 0.06 | 1.04 ± 0.10 | 1.12 ± 0.08 |
| JD of cinguli | 1.03 ± 0.08 | 1.01 ± 0.08 | 0.97 ± 0.08 |
AD, Alzheimer's disease; a‐MCI, amnestic‐mild cognitive involvement; HS, healthy subjects; ACC, anterior cingulated cortex; SFG, superior frontal gyrus; FA, fractional anisotropy; GM, gray matter; MD, mean diffusivity.
GM density was extracted from four clusters located in the posterior and anterior cingulate cortex, and in the right and left hippocampal/parhahippocampal areas. These clusters were obtained by whole brain comparison between patients with AD and HS, at a statistical thereshold of p FWEcorrected < 0.05. In the case of the hippocampal/parhahippocampal regions, the table reports the average value between right and left side (see text for further details).