. Author manuscript; available in PMC: 2020 Nov 1.

Published in final edited form as: Obstet Gynecol. 2019 Nov;134(5):921–931. doi: 10.1097/AOG.0000000000003503

Table 3.

Cost estimates

Variable	Cost (in 2017 USD, range for sensitivity analysis)
Methadone, initial month	$22,612 (22,584–23,114)^25,34–37
Methadone, subsequent month	$2,540–6,400, based on gestational age²⁵
Buprenorphine, initial month	$22,306 (21,088–24,014)^25,34–37
Buprenorphine, subsequent month	$968–5,257, based on gestational age²⁵
Detoxification, initial month	$10,366 (9,488–11,640)^{25,34–37,41}
Detoxification, subsequent month	$920–4,780, based on gestational age^{25,34–37,41}
Detoxification cost multiplier^*	2 (1–3) (consensus)
Cost of methadone treatment, residential, initial month	$6,354 (2,448–10,114)^24,25
Cost of methadone treatment, residential, subsequent month	$7,117 (2,751–11,283)^24,25
Cost of residential treatment, initial month	$6,968 (3,114–10,823)^24,25
Cost of residential treatment, subsequent month	$7,787 (3,504–12,069)^24,25
Medication cost of methadone outpatient (including outpatient nursing administration), per month	$1,646 (1,458–1,980)²⁵
Medication cost of buprenorphine, per month	$200 (58–558)³⁵
Maternal overdose	$40,496–41,606, based on gestational age^25,34–37
Birth	$3,841 (3,810–3,986)⁶
Treatment of fetal loss/miscarriage	$1,402³⁸
NAS treatment, NICU	$19,340 (18,290–20,390)⁶
NAS treatment, rooming in	$8,795 (5,327–14,203)³³
Admission to NICU < 37w	24w-28w: $90,978³⁹ 28w-32w: $53,880³⁹ 32w-36w: $16,780³⁹

NAS, neonatal abstinence syndrome; NICU, neonatal intensive care unit

Detoxification cost multiplier was used to vary the cost of inpatient and outpatient management for women undergoing detoxification