. Author manuscript; available in PMC: 2020 Nov 1.

Published in final edited form as: Obstet Gynecol. 2019 Nov;134(5):921–931. doi: 10.1097/AOG.0000000000003503

Table 6.

Events among 20,000 women

Outcome	Event number per strategy: n( 95% CI)
	Methadone	Buprenorphine	Detoxification
Maternal relapse	13,153 (12,633–13,676)	5,541 (5,365–5,721)	15,459 (15,161–15,761)
Overdose, fatal and nonfatal	25 (16–35)	9 (4–15)	178 (152–205)
Preterm birth (<37 weeks)	642 (593–691)	642 (593–691)	642 (593–691)
NAS	9,739 (9,602–9,878)	8,085 (7,949–8,222)	3,930 (3,819–4,040)
NICU admission	9,926 (9,789–10,065)	8,379 (8,242–8,518)	4,502 (3,486–4,618)
Switch to methadone	N/A	2,087 (2,003–2,172)	6,878 (6,746–7,011)

NAS, neonatal abstinence syndrome; NICU, neonatal intensive care unit