Table II.
Brain regions with significant nonlinearity of lifespan GMV trajectory
| Brain region | Hemisphere | Cluster size in voxels | Voxel t‐value (FWE‐cor.) | Peak MNI coord. (mm) | Explained variance gain due to quad. predictor (%) | Age of max. GMV in mean quadratic regression (yr) | Age of max. change of slope of smoothing spline (yr) | ||
|---|---|---|---|---|---|---|---|---|---|
| x | y | z | |||||||
| Hippocampus/amygdala | Left | 1003 | 8.99 | −28 | −15 | −18 | 14 | 41.3 | 59 |
| Cerebellum lob. V/VI (Hem.) | Right | 1935 | 8.61 | 15 | −54 | −17 | 7 | 30.8 | 54 |
| Hippocampus/amygdala | Right | 843 | 7.76 | 30 | −13 | −20 | 11 | 40.2 | 59 |
| Cerebellum lob. VII (Hem.) | Right | 1014 | 7.09 | 20 | −61 | −57 | 7 | 33.2 | 57 |
| Cerebellum lob. VI/VII (Hem.) | Left | 880 | 7.05 | −20 | −55 | −18 | 6 | 31.8 | 55 |
| Striatum | Right | 199 | 7.03 | 18 | 10 | −9 | 6 | 32.5 | 56 |
| Parietal operculum | Left | 91 | 6.86 | −36 | −19 | 16 | 5 | 26.6 | 55 |
| Parietal operculum | Right | 91 | 6.64 | 36 | −16 | 16 | 4 | 23.1 | 50 |
| Orbitofrontal cortex | Left | 64 | 6.57 | −27 | 35 | −17 | 7 | 34.5 | 59 |
| Nucleus caudate | Left | 66 | 6.40 | −12 | 20 | 0 | 4 | 30.5 | 55 |
| Cerebellum lob. VII (Hem.) | Left | 212 | 6.26 | −20 | −79 | −35 | 5 | 33.3 | 54 |
| Putamen | Left | 93 | 6.23 | −16 | 8 | −12 | 5 | 30.2 | 52 |
| Cerebellum lob. VIII (Vermis) | Right | 72 | 5.99 | 6 | −72 | −44 | 5 | 33.4 | 57 |
Listed are cluster size, peak t‐values with coordinates, percentage increase of explained variance of GMV by inclusion of a quadratic age predictor, ages of maximum GMV in quadratic model, and the ages of maximum change of slope in the smoothing spline model. All reported brain regions are significant with voxel threshold t = 4.83 (P < 0.05) and extent threshold k = 50 voxels (P < 0.0001) using FWE correction.