Table II.

Functional networks associated with MSIT performance (separate ICA)

Healthy subjects	Anatomy a			Stats b			OCD patients	Anatomy a			Stats b			Difference c	Anatomy a			Stats c
	x	y	z	KE	Z			x	y	z	KE	Z			x	y	z	KE	Z
Paralimbic Network							Paralimbic Network							Paralimbic Network
Dorsal anterior cingulate	3	36	30	3858	>8		Dorsal anterior cingulate	0	3	51	871	6.25		Healthy subjects > OCD
	6	9	42		>8		/Supplementary motor							Dorsal anterior cingulate	3	36	30	601	6.57
Anterior insular/Opercular cortices	−33	15	3	713	7.16		Anterior insular/Opercular cortices	−42	15	−9	987	>8		Mid‐cingulate cortex	3	−24	39	67	5.80
							Anterior insular/Opercular cortices	42	27	−3	1189	>8
Anterior insular/Opercular cortices	39	27	−3	689	6.69		Motor/Premotor cortex	−45	−3	39	278	5.19		OCD > Healthy subjects
							Medial frontal cortex	−27	42	33	60	4.97		Anterior insular/Opercular cortices	48	27	−6	130	5.85
Medial frontal cortex	−33	33	33	336	6.30		Red nucleus/Sub‐and Thalamic nuclei	15	−12	3	42	4.15
Medial frontal cortex	33	57	30	317	5.76									Anterior insular/Opercular cortices	−45	15	−9	161	5.79
Pulvinar/Thalamic, Red and	−12	−21	−3	176	5.03		Globus Pallidus	−12	−3	3	39	5.42
Subthalamic nuclei	12	−18	−3		4.46		Caudate nucleus/Putamen	18	12	3	43	4.78
Intraparietal cortex	−36	−57	39	75	4.34		Ventral medial frontal cortex	3	48	6	31	4.36
Intraparietal cortex	33	−60	42	61	4.18
Premotor/Frontal eye field	−27	−12	51	59	4.02
Cerebellum	6	−36	−30	43	4.40
Sensorimotor Network							Sensorimotor Network							Sensorimotor Network
Sensorimotor cortex	−39	−45	66	3778	>8		Somatosensory cortex	42	−57	63	1186	7.65		Healthy subjects > OCD
Motor/Supplementary motor cortices	−39	−30	66		>8		Sensorimotor cortex	45	−42	66		7.29		Motor/Sensorimotor cortices	−18	−30	69	11	4.55
							Primary motor cortex	45	−33	39		7.06
Motor/Supplementary motor cortices	36	−15	69	235	6.13		Somatosensory cortex	−63	−36	36	2250	7.54
							Sensorimotor cortex	−45	−48	48		6.76		OCD > Healthy subjects
Somatosensory cortex	33	−24	72		4.71		Motor cortex	−24	−15	60		6.24		Sensorimotor cortex	51	−27	33	78	4.36
Somatosensory/Superior parietal cortices	21	−75	60	558	6.01		Superior parietal cortex	−27	−63	51		5.07		Primary motor cortex	30	−12	60	28	4.08
Cerebellum	3	−78	−30	316	5.65		Supplementary motor cortex	30	−12	54	380	6.94
							Cerebellum	0	−60	−33	417	5.70
Pulvinar/Thalamic nuclei	−15	−24	3	28	4.62		Pulvinar/Thalamic nuclei	−12	−24	3	96	6.60
Fronto‐Parietal Network							Fronto‐Parietal Network							Fronto‐Parietal Network
Superior parietal cortex	−48	−48	36	1880	>8		Superior parietal cortex	−42	−78	39	1774	>8		Healthy subjects > OCD
Superior parietal cortex	30	−75	30	864	6.26		Superior parietal cortex	36	−84	42	153	4.65		No differences
Dorsolateral prefrontal cortex	−48	18	36	2172	>8		Dorsolateral prefrontal cortex	−51	24	18	1923	7.55
							Supplementary motor cortex	−3	12	54		5.37		OCD > Healthy subjects
Supplementary motor cortex	−6	9	54		6.19		Dorsolateral prefrontal cortex	45	51	15	50	5.34		No differences
Dorsolateral prefrontal cortex	51	33	27	13	4.11		Insula	−42	15	−6	14	3.81
Cerebellum	−45	−69	−30	136	6.80
Caudate	9	12	6	34	4.26
Caudate	−12	15	3	124	3.70
Insula	−33	21	−3	79	4.89
Default Mode Network							Default Mode Network							Default Mode Network
Medial frontal cortex	0	42	33	3589	>8		Medial frontal cortex	0	42	33	3163	>8		Healthy subjects > OCD
Angular gyrus	−51	−75	18	311	>8		Angular gyrus	−48	−72	18	303	6.81		Medial frontal cortex	3	51	15	35	4.50
Angular gyrus	60	−66	12	97	5.82		Angular gyrus	57	−72	21	268	6.31		Dorsal prefrontal cortex	24	33	54	10	4.42
Posterior cingulate	−3	−63	21	528	6.63		Posterior cingulate	−6	−57	24	288	6.28
Operculum/Inferior frontal cortices	−45	30	−15	197	4.83		Operculum/Inferior frontal cortices	−51	18	−3	75	5.60		OCD > Healthy subjects
							Medio‐temporal gyrus	63	−12	−18	78	5.53		Pre‐Supplementary motor cortex	3	24	54	18	4.23
Operculom/Inferior frontal cortices	48	33	−18	69	5.89		Medio‐temporal gyrus	−51	−18	−18	13	3.90
														Supplementary motor cortex	−12	15	57	19	4.05
Caudate nucleus	15	6	12	84	5.28
Thalamic nuclei	6	−9	3	19	3.96

^aActivity coordinates (x, y, z) are given in Montreal Neurological Institute (MNI) Atlas space.

^bMagnitude and extent statistics correspond to a minimum threshold of P _FDR < 0.01 (whole‐brain corrected), K _E (minimal cluster extent)= 10 voxels.

^cResults correspond to statistical differences of P < 0.001 (uncorrected), K _E = 10 voxels.