Table II.
Clusters derived from the voxel based comparisons between participant groups
| Contrasts and brain regions (BA areas) | MNI coordinates (cluster maxima) | t (cluster maxima) | P (cluster level, corrected) | Cluster size | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Dep > control | ||||||
| *ACC, MFG_R, (32, 10) | 12 | 45 | 9 | 3.99 | <0.001 | 85 |
| ACC, MFG_L, (10) | −9 | 48 | 12 | 3.90 | <0.001 | 48 |
| *Insula_R, (13) | 33 | −12 | 18 | 3.87 | <0.001 | 20 |
| *Parahippocampal gyrus_R, (28) | 24 | −18 | −9 | 3.66 | <0.001 | 22 |
| Dep < control | ||||||
| *PFG_L, (19) | −33 | −78 | −18 | 4.87 | <0.001 | 42 |
| Lateral inferior frontal gyrus_L, (44) | −48 | 9 | 24 | 4.28 | <0.001 | 36 |
| Caudate body and adjacent white matter_L | −21 | −24 | 27 | 3.56 | <0.001 | 20 |
| IPL_L, (40, 2) | −48 | −27 | 39 | 3.53 | <0.001 | 52 |
| *Inferior medial prefrontal cortex_L, (10, 11) | −15 | 45 | −21 | 3.19 | <0.001 | 30 |
| TRD > NDD | ||||||
| Middle temporal gyrus_R, (22, 21) | 57 | −39 | 0 | 4.67 | <0.001 | 41 |
| Insula_R, (13) | 36 | −21 | 12 | 3.97 | <0.001 | 23 |
| Middle cingulate, MFG, (24, 31) | −3 | −15 | 45 | 3.85 | <0.001 | 66 |
| TRD < NDD | ||||||
| *Precuneus_L, (7) | −12 | −78 | 54 | 4.03 | <0.001 | 40 |
| Inferior frontal gyrus_L, (9, 6) | −48 | 0 | 27 | 3.49 | <0.001 | 31 |
| NDD > control | ||||||
| Medial prefrontal gyrus_L,(9) | −9 | 54 | 24 | 3.79 | <0.001 | 29 |
| Parahippocampal gyrus_R, (28) | 24 | −21 | −9 | 3.69 | <0.001 | 24 |
| NDD < control | ||||||
| PFG_L, (19) | −33 | −78 | −18 | 4.18 | <0.001 | 28 |
| TRD > control | ||||||
| Insula, Transverse temporal gyrus_R, (13, 41) | 33 | −12 | 18 | 4.49 | <0.001 | 31 |
| ACC, MFG_L, (9, 32) | −9 | 48 | 12 | 4.17 | <0.001 | 50 |
| MFG_L, (6) | −12 | −12 | 66 | 3.94 | <0.001 | 21 |
| ACC, MFG_R, (32, 10) | 15 | 48 | 0 | 3.46 | <0.001 | 86 |
| Superior and middle temporal gyrus_R, (21, 22) | 57 | −39 | 3 | 3.37 | <0.001 | 21 |
| TRD < control | ||||||
| Lateral inferior frontal gyrus_L, (45, 9) | −54 | 9 | 21 | 4.79 | <0.001 | 73 |
| *PFG_L, (19) | −33 | −78 | −18 | 3.98 | <0.001 | 20 |
| IPL_L, (3, 40) | −45 | −24 | 51 | 3.95 | <0.001 | 166 |
| IPL_R, (40) | 54 | −42 | 48 | 3.46 | <0.001 | 23 |
| Superior parietal lobule, Precuneus_L, (7) | −24 | −66 | 54 | 3.38 | <0.001 | 48 |
Abbreviations: ACC, anterior cingulate cortex; PFG, posterior fusiform gyrus; IPL, inferior parietal lobule; MFG, medial frontal gyrus. Labels * indicate clusters which show significant correlations between ReHo values and disease severity measures.