Table III.
Empathy regions with different activity in somatoform disorder patients
| All emotions ([“anger”+ “disgust” + “happy” + “neutral”] – “control”) | ||||||||
| Somatoform patients < healthy subjects, P [uncorrected] ≤ 0.001, minimum cluster size 10 voxel | ||||||||
| Region | x | y | z | T | n | P [FWE] | T [20/14]* | |
| Right Parahippocampal gyrus | 30 | 54 | −3 | 4.851 | 22 | 0.664 | 4.149 | |
| Left Amygdala | −24 | −3 | −24 | 5.051 | 19 | 0.828 | 4.129 | |
| *All T [20/14] values correspond to P [uncorrected] ≤ 0.001 | ||||||||
| Somatoform patients > healthy subjects, P [uncorrected] ≤ 0.001, minimum cluster size 10 voxel no region | ||||||||
| Anger (“anger” – “control”) | ||||||||
| somatoform patients < healthy subjects, P [uncorrected] ≤ 0.001, minimum cluster size 10 voxel | ||||||||
| Region | x | y | z | T | n | P [FWE] | T [20/14]* | |
| Left postcentral gyrus | −15 | 39 | 66 | 4.294 | 21 | 0.899 | 3.223 | |
| Left superior temporal gyrus | −33 | −15 | −27 | 4.165 | 15 | 0.998 | 3.616 | |
| Left parahippocampal gyrus | −33 | 18 | −24 | 4.319 | 15 | 0.998 | 3.656 | |
| Right parahippocampal gyrus | 18 | 21 | −15 | 4.736 | 13 | 0.999 | 4.972 | |
| Left posterior insula | −36 | 33 | 15 | 4.653 | 13 | 0.999 | 4.375 | |
| Left Amygdala | −21 | −3 | −21 | 4.913 | 17 | 0.978 | 5.047 | |
| Left Cerebellum | −36 | 81 | −24 | 4.635 | 14 | 0.999 | 4.646 | |
| *All T [20/14] values correspond to P [uncorrected] ≤ 0.0029 | ||||||||
| Somatoform patients > healthy subjects, P [uncorrected] ≤ 0.001, minimum cluster size 10 voxel no region | ||||||||
| Disgust (“disgust” – “control”) | ||||||||
| Somatoform patients < healthy subjects, P [uncorrected] ≤ 0.001, minimum cluster size 10 voxel no region | ||||||||
| Somatoform patients > healthy subjects, P [uncorrected] ≤ 0.001, minimum cluster size 10 voxel no region | ||||||||
| Joy (“joy” – “control”) | ||||||||
| Somatoform patients < healthy subjects, P [uncorrected] ≤ 0.001, minimum cluster size 10 voxel | ||||||||
| Region | x | y | z | T | n | P [FWE] | T [20/14]* | |
| Right Parahippocampal gyrus | 30 | 54 | −3 | 4.533 | 22 | 0.472 | 3.601 | |
| Right Cerebellum | 33 | 84 | −27 | 4.811 | 11 | 0.997 | 4.455 | |
| Right Cerebellum | 21 | 87 | −30 | 4.131 | 10 | 0.999 | 5.061 | |
| *All T [20/14] values correspond to P [uncorrected] ≤ 0.0011 | ||||||||
| Somatoform patients > healthy subjects, P [uncorrected] ≤ 0.001, minimum cluster size 10 voxel no region | ||||||||
| Neutral (“neutral” – “control”) | ||||||||
| Somatoform patients < healthy subjects, P [uncorrected] ≤ 0.001, minimum cluster size 10 voxel no region | ||||||||
| Somatoform patients > healthy subjects, P [uncorrected] ≤ 0.001, minimum cluster size 10 voxel no region | ||||||||
Active clusters of the contrasts “all emotions” – “control,” “anger” – “control,” “disgust” – “control,” “joy” – “control,” and “neutral” – “control”; voxel‐based independent samples t‐test comparing healthy subjects (n = 20) and somatoform patients (n = 20). x, y, and z coordinates belong to the peak voxel of the cluster and refer to the Talairach and Tournoux stereotactical space. T‐values refer to the peak voxel; n represents the number of voxels in the cluster; P [FWE] describes the family‐wise error of a cluster of the given size; T [20/14] reflects the T score of the same peak voxel using a contrast, which included the 20 healthy controls and the 14 nonmedicated patients.