Table III.
FA and MD voxel‐wise comparison
| Region | Cluster P corr | Cluster size | MNI coord [X Y Z] | Anatomical extent of cluster | T value | Mean FA | Mean MD (× 10−3 mm2 s−1) | Mean RD (×10−3 mm2 s−1) | Mean PD (102 mm2 s−1) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PA C+ | PA C− | HC | PA C+ | PA C− | HC | PA C+ | PA C− | HC | PA C+ | PA C‐ | HC | ||||||
| FA voxel‐wise comparison | |||||||||||||||||
| Frontal | <0.0001 | 599 | [21 12 24] | Cluster covering parts of : superior fronto‐occipital fasciculus, anterior limb of internal capsula, superior corona radiata | 5.36 | 0.39a , b | 0.43 | 0.43 | 0.75a , b | 0.70 | 0.70 | 0.58a , b | 0.52 | 0.52 | 0.11 | 0.10 | 0.11 |
| Temporal | 0.01 | 227 | [36 −45 −6] | Sagittal stratum (includes inferior longitudinal and inferior fronto‐occipital fasciculus) | 5.61 | 0.42a , b | 0.46 | 0.47 | 0.93a , b | 0.88 | 0.89 | 0.71a , b | 0.64 | 0.65 | 0.14 | 0.14 | 0.14 |
| MD voxel‐wise comparison | |||||||||||||||||
| Frontal | <0.0001 | 1164 | [30 14 26] | Cluster covering parts of : superior longitudinal fasciculus, superior corona radiata, corpus callosum and cingulum | 5.84 | 0.38a , b | 0.42 | 0.42 | 0.76a , b | 0.69 | 0.71 | 0.60a , b | 0.52 | 0.54 | 0.11 | 0.10 | 0.10 |
FA voxel‐wise comparison: clusters where FA value is significantly lower in chemo‐therapy treated patients than healthy controls (P < 0.05, corrected for multiple comparisons). Mean FA, MD, RD, and PD values are calculated and reported for those identified clusters.
MD voxel‐wise comparison: clusters where MD value is significantly higher in chemo‐therapy treated patients than healthy controls (P < 0.05, corrected for multiple comparisons). Mean FA, MD, RD, and PD values are calculated and reported for those identified clusters.
PA C+: patients who received chemotherapy; PA C−: patients who did not receive chemotherapy; HC: healthy controls; FA: fractional anisotropy; MD: mean diffusivity; RD: radial diffusivity; PD: parallel diffusivity.
Mean chemotherapy‐treated patient group significantly different (P < 0.05) from mean healthy control group.
Mean chemotherapy‐treated patient group significantly different (P < 0.05) from mean non‐chemotherapy‐treated patient control group.
Note: no significant differences were found between mean C− patient control group and mean healthy control group.