Figure 2.

Schematic of hippocampal shape analysis. Panel (a) shows the large deformation diffeomorphic metric surface mapping (LDDMM‐surface) from a hippocampal surface atlas to subjects' surfaces, S _i and S _j, and obtained the initial momentum characterizing shape variations of S _i and S _j relative to the atlas surface. Panel (b) illustrates the representation of hippocampal shapes of 302 healthy subjects into a two‐dimensional Euclidean space that was obtained using locally linear diffeomorphic metric embedding (LLDME). Panel (b) also illustrates real hippocampal shapes at six different locations marked as set 1, 2, …, 6.