Table IV.
Maximum likelihood parameter estimates and P‐values from hypothesis testing of univariate ACE models
| Variance components (95% CI) | Hypothesis test (P‐values*) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| a 2 | c 2 | e 2 | A | C | A and C | ||||
| Superior Frontal Gyrus ‐R | 0.45 | (0.20, 0.60) | 0.00 | (0.00, 0.15) | 0.55 | (0.40, 0.72) | 0.004 | 1.000 | 0.00 |
| Superior Frontal Gyrus ‐L | 0.51 | (0.24, 0.64) | 0.00 | (0.00, 0.17) | 0.49 | (0.36, 0.65) | 0.002 | 1.000 | 0.00 |
| Middle Frontal Gyrus ‐R | 0.43 | (0.21, 0.59) | 0.00 | (0.00, 0.10) | 0.57 | (0.41, 0.76) | 0.002 | 1.000 | 0.00 |
| Middle Frontal Gyrus ‐L | 0.38 | (0.05, 0.52) | 0.00 | (0.00, 0.21) | 0.62 | (0.48, 0.80) | 0.027 | 1.000 | 0.00 |
| Inferior Frontal Gyrus ‐R | 0.52 | (0.32, 0.66) | 0.00 | (0.00, 0.09) | 0.48 | (0.34, 0.67) | 0.000 | 1.000 | 0.00 |
| Inferior Frontal Gyrus ‐L | 0.44 | (0.15, 0.58) | 0.00 | (0.00, 0.19) | 0.56 | (0.42, 0.73) | 0.007 | 1.000 | 0.00 |
| Precentral Gyrus ‐R | 0.43 | (0.20, 0.58) | 0.00 | (0.00, 0.13) | 0.57 | (0.42, 0.75) | 0.004 | 1.000 | 0.00 |
| Precentral Gyrus ‐L | 0.52 | (0.27, 0.65) | 0.00 | (0.00, 0.15) | 0.48 | (0.35, 0.65) | 0.001 | 1.000 | 0.00 |
| Lateral Orbitofrontal Gyrus ‐R | 0.38 | (0.12, 0.54) | 0.00 | (0.00, 0.15) | 0.62 | (0.46, 0.81) | 0.010 | 1.000 | 0.00 |
| Lateral Orbitofrontal Gyrus ‐L | 0.34 | (0.03, 0.49) | 0.00 | (0.00, 0.19) | 0.66 | (0.51, 0.84) | 0.037 | 1.000 | 0.00 |
| Medial Orbitofrontal Gyrus ‐R | 0.22 | (0.00, 0.38) | 0.00 | (0.00, 0.17) | 0.78 | (0.62, 0.96) | 0.099 | 1.000 | 0.05 |
| Medial Orbitofrontal Gyrus ‐L | 0.27 | (0.00, 0.43) | 0.00 | (0.00, 0.21) | 0.73 | (0.57, 0.91) | 0.087 | 1.000 | 0.01 |
| Cingulate ‐R | 0.36 | (0.16, 0.53) | 0.00 | (0.00, 0.09) | 0.64 | (0.47, 0.83) | 0.003 | 1.000 | 0.00 |
| Cingulate ‐L | 0.40 | (0.18, 0.56) | 0.00 | (0.00, 0.10) | 0.60 | (0.44, 0.80) | 0.003 | 1.000 | 0.00 |
| Medial Frontal Gyrus ‐R | 0.38 | (0.10, 0.54) | 0.00 | (0.00, 0.17) | 0.62 | (0.46, 0.80) | 0.016 | 1.000 | 0.00 |
| Medial Frontal Gyrus ‐L | 0.50 | (0.27, 0.64) | 0.00 | (0.00, 0.13) | 0.50 | (0.31, 0.68) | 0.001 | 1.000 | 0.00 |
| Superior Parietal Gyrus ‐R | 0.44 | (0.20, 0.59) | 0.00 | (0.00, 0.13) | 0.56 | (0.41, 0.76) | 0.004 | 1.000 | 0.00 |
| Superior Parietal Gyrus ‐L | 0.30 | (0.04, 0.47) | 0.00 | (0.00, 0.15) | 0.70 | (0.54, 0.89) | 0.032 | 1.000 | 0.01 |
| Supramarginal Gyrus ‐R | 0.39 | (0.00, 0.53) | 0.00 | (0.00, 0.28) | 0.61 | (0.47, 0.79) | 0.056 | 1.000 | 0.00 |
| Supramarginal Gyrus ‐L | 0.51 | (0.22, 0.63) | 0.00 | (0.00, 0.21) | 0.49 | (0.37, 0.64) | 0.003 | 1.000 | 0.00 |
| Angular Gyrus ‐R | 0.20 | (0.00, 0.39) | 0.00 | (0.00, 0.18) | 0.80 | (0.61, 0.99) | 0.171 | 1.000 | 0.12 |
| Angular Gyrus ‐L | 0.24 | (0.00, 0.41) | 0.00 | (0.00, 0.18) | 0.76 | (0.59, 0.95) | 0.113 | 1.000 | 0.04 |
| Precuneus ‐R | 0.19 | (0.00, 0.36) | 0.00 | (0.00, 0.21) | 0.81 | (0.64, 0.98) | 0.227 | 1.000 | 0.09 |
| Precuneus ‐L | 0.12 | (0.00, 0.28) | 0.00 | (0.00, 0.16) | 0.88 | (0.72, 1.00) | 0.367 | 1.000 | 0.32 |
| Postcentral Gyrus ‐R | 0.57 | (0.36, 0.68) | 0.00 | (0.00, 0.13) | 0.43 | (0.32, 0.58) | 0.000 | 1.000 | 0.00 |
| Postcentral Gyrus ‐L | 0.48 | (0.25, 0.61) | 0.00 | (0.00, 0.14) | 0.52 | (0.39, 0.68) | 0.001 | 1.000 | 0.00 |
| Superior Temporal Gyrus ‐R | 0.41 | (0.13, 0.56) | 0.00 | (0.00, 0.17) | 0.59 | (0.44, 0.77) | 0.010 | 1.000 | 0.00 |
| Superior Temporal Gyrus ‐L | 0.40 | (0.14, 0.55) | 0.00 | (0.00, 0.16) | 0.60 | (0.45, 0.77) | 0.007 | 1.000 | 0.00 |
| Middle Temporal Gyrus ‐R | 0.33 | (0.00, 0.49) | 0.00 | (0.00, 0.21) | 0.67 | (0.51, 0.86) | 0.047 | 1.000 | 0.00 |
| Middle Temporal Gyrus ‐L | 0.39 | (0.04, 0.54) | 0.00 | (0.00, 0.22) | 0.61 | (0.46, 0.80) | 0.031 | 1.000 | 0.00 |
| Inferior Temporal Gyrus ‐R | 0.38 | (0.17, 0.53) | 0.00 | (0.00, 0.12) | 0.62 | (0.47, 0.70) | 0.003 | 1.000 | 0.00 |
| Inferior Temporal Gyrus ‐L | 0.47 | (0.18, 0.60) | 0.00 | (0.00, 0.20) | 0.53 | (0.40, 0.69) | 0.004 | 1.000 | 0.00 |
| Uncus ‐R | 0.01 | (0.00, 0.16) | 0.00 | (0.00, 0.09) | 0.99 | (0.84, 1.00) | 1.000 | 1.000 | 1.00 |
| Uncus ‐L | 0.05 | (0.00, 0.24) | 0.00 | (0.00, 0.10) | 0.95 | (0.76, 1.00) | 0.584 | 1.000 | 0.86 |
| Medial Occipitotemporal Gyrus ‐R | 0.31 | (0.00, 0.47) | 0.01 | (0.00, 0.30) | 0.68 | (0.53, 0.87) | 0.196 | 0.938 | 0.00 |
| Medial Occipitotemporal Gyrus ‐L | 0.26 | (0.00, 0.42) | 0.00 | (0.00, 0.22) | 0.74 | (0.59, 0.92) | 0.128 | 1.000 | 0.01 |
| Lateral Occipitotemporal Gyrus ‐R | 0.33 | (0.00, 0.48) | 0.00 | (0.00, 0.22) | 0.67 | (0.52, 0.85) | 0.052 | 1.000 | 0.00 |
| Lateral Occipitotemporal Gyrus ‐L | 0.28 | (0.00, 0.44) | 0.00 | (0.00, 0.20) | 0.72 | (0.56, 0.90) | 0.074 | 1.000 | 0.01 |
| Parahippocampal Gyrus ‐R | 0.06 | (0.00, 0.24) | 0.01 | (0.00, 0.16) | 0.93 | (0.76, 1.00) | 0.808 | 0.929 | 0.61 |
| Parahippocampal Gyrus ‐L | 0.10 | (0.00, 0.33) | 0.06 | (0.00, 0.25) | 0.84 | (0.67, 0.98) | 0.651 | 0.705 | 0.07 |
| Occipital Pole ‐R | 0.30 | (0.00, 0.50) | 0.05 | (0.00, 0.32) | 0.65 | (0.50, 0.84) | 0.183 | 0.764 | 0.00 |
| Occipital Pole ‐L | 0.47 | (0.09, 0.60) | 0.00 | (0.00, 0.27) | 0.53 | (0.40, 0.70) | 0.018 | 1.000 | 0.00 |
| Superior Occipital Gyrus ‐R | 0.37 | (0.01, 0.52) | 0.00 | (0.00, 0.24) | 0.63 | (0.48, 0.81) | 0.045 | 1.000 | 0.00 |
| Superior Occipital Gyrus ‐L | 0.31 | (0.00, 0.48) | 0.00 | (0.00, 0.30) | 0.69 | (0.52, 0.91) | 0.216 | 1.000 | 0.01 |
| Middle Occipital Gyrus ‐R | 0.26 | (0.00, 0.43) | 0.00 | (0.00, 0.22) | 0.74 | (0.57, 0.94) | 0.136 | 1.000 | 0.02 |
| Middle Occipital Gyrus ‐L | 0.33 | (0.04, 0.51) | 0.00 | (0.00, 0.16) | 0.67 | (0.49, 0.87) | 0.032 | 1.000 | 0.01 |
| Inferior Occipital Gyrus ‐R | 0.23 | (0.00, 0.40) | 0.00 | (0.00, 0.21) | 0.77 | (0.60, 0.96) | 0.193 | 1.000 | 0.04 |
| Inferior Occipital Gyrus ‐L | 0.12 | (0.00, 0.49) | 0.21 | (0.00, 0.39) | 0.67 | (0.50, 0.83) | 0.580 | 0.200 | 0.00 |
| Cuneus ‐R | 0.35 | (0.02, 0.50) | 0.00 | (0.00, 0.22) | 0.65 | (0.50, 0.83) | 0.039 | 1.000 | 0.00 |
| Cuneus ‐L | 0.15 | (0.00, 0.32) | 0.00 | (0.00, 0.19) | 0.85 | (0.68, 1.00) | 0.307 | 1.000 | 0.25 |
| Lingual Gyrus ‐R | 0.01 | (0.00, 0.33) | 0.13 | (0.00, 0.25) | 0.86 | (0.67, 0.98) | 1.000 | 0.349 | 0.06 |
| Lingual Gyrus ‐L | 0.22 | (0.00, 0.39) | 0.00 | (0.00, 0.24) | 0.78 | (0.61, 0.97) | 0.325 | 1.000 | 0.06 |
| Insula ‐R | 0.30 | (0.00, 0.46) | 0.00 | (0.00, 0.20) | 0.70 | (0.54, 0.88) | 0.059 | 1.000 | 0.01 |
| Insula ‐L | 0.26 | (0.00, 0.43) | 0.00 | (0.00, 0.20) | 0.74 | (0.57, 0.95) | 0.120 | 1.000 | 0.03 |
*
P‐values test the hypotheses of no genetic (A), shared environmental (C), or familial (A and C) effects on phenotypic variance; statistically significant effects (at an α=0.05) are shown in boldface.