Table II.

Regions of significantly increased gray matter mean diffusivity in patients with primary progressive multiple sclerosis (PPMS) compared to controls (P < 0.001)

Anatomical regions	PPMS vs controls
	Side	BA	SPM coordinates	t value
Middle frontal gyrus	L	47	−40, −42, −4	4.45
	L	9	−36, 8, 36	3.99
Cingulated gyrus	R	32	6, 30, 22	4.84
	R	29	6, −42, 20	4.52
	L	32	−4, 26, −6	4.23
Insula	R	13	46, 8, 6	3.81
	L	13	−34, −14, 6	5.50
Thalamus	R	–	14, −24, 2	4.73
	L	–	−12, −26, −6	4.85
Caudate nucleus	R	–	6, 4, −6	6.08
	L	–	−2, 6, −8	5.18
Inferior parietal lobe	L	40	−54, −46, 22	4.58
	L	40	−60, −26, 32	4.53
Superior temporal gyrus	L	42	−56, −14, 12	4.58
	L	41	−54, −23, 5	4.06
Middle temporal gyrus	R	21	60, −52, 2	4.67
	L	22	−58, −38, −6	5.67
Inferior temporal gyrus	R	30	42, −50, −16	4.00
	L	20	−50, −52, −14	5.04
	L	35	−16, –18, −18	4.71
Lingual gyrus	R	19	30, −60, −6	4.24
	L	17	−12, −92, −4	4.15
Precuneus	L	31	−12, −54, 28	3.84
Cuneus	R	31	22, −56, 22	4.09
	R	18	8, −82, 22	3.96
Cerebellum	R	–	32, 66, −40	4.08
	R	–	2, −74, −20	3.96
	L	–	−16, −76, −40	4.44

PPMS, primary progressive multiple sclerosis; R, right; L, left; BA, Brodman area.

See the text for further details.