Table I.

Activations and deactivations in anosmics and controls

Region	Controls			Anosmics
	Z level	Size, cm3	Coordinates	Z level	Size, cm3	Coordinates
Activations in anosmics and controls
ACE‐AIR
R insular cortex (includes amygd + pirif cortex + caudate + anterior cingulated)	6.5	9.0	38, −10, 6
R caudate
L insular cortex (including the postcentral gyrus)	5.2	5.0	−30, −6, 0	3.0	1.4	−50, 10, 30a
Ant cingulate				3.5	5.6	−22, 44, 8
Hypothalamus and thalamusb	3.5	2.8	16, −10, −20	4.2	2.2	2, −36, −6
	4.2	5.0	8, −32, −20			12, 2, 16
	5.1	2.4	−2, −2, −6
Cerebellum	4.3	0.8	−48, −50, −28
VAN‐AIR
R pirif + amygd	5.1	1.6	20, −4, −20
L pirif + amygd	4.8	0.9	−20, −4, −16
L fusiform gyrus	4.3	1.3	−48, −42, −26
AND‐AIR
R pirif + amygd	4.5	0.9	36, −14, −6
R lingular + fusiform gyri	4.2	1.2	18, −60, −24
EST‐AIR
Anterior hypothalamus	4.6	1.2	6, −12, 2
L pirif + amygd	4.5	1.0	−22, −6, 24
Deactivations in anosmics and controls
AIR‐ACE
R superior temporal gyrus	4.5	1.6	54, −12, −6	4.5	1.6	54, −12, −6
R, L middle temporal gyrus	4.4	1.2	38, −42, −14	4.5	3.2	42, −68, 8
	3.3	3.2	38, −18, −20			38, −62, 12
Parieto‐occipital cortex	4.5	33	12, −68, 16	5.0	6.2	−10, −82, 34
	3.3	2.8	−38, −36, 30
AIR‐AND
Medial prefrontal cortex	3.7	2.5	4, 46, 20
AIR‐EST
Anterior cingulate	3.6	3.3	6, 58, 0
AIR‐VAN
Medial prefrontal cortex	4.5	5.6	38, 46, 8
	4.8	3.6	−14, 45, 2
Middle temporal gyrus	4.4	1.2	−40, −44, 6
Cuneus, fusiform gyrus	4.3	3.6	46, −74, −16

Values calculated using one group random effect analysis, with a height threshold at P = 0.001, and corrected P < 0.05. The Talairach's coordinates indicate the peak activation; the indicated regions describe the coverage of the respective cluster. pirif, piriform cortex; amygd, amygdale.

^aIncludes only a portion of the granular insular cortex.

^bIncludes the ventromedial nucleus and the pulvinar.