Table III.
ANOVA differences in brain activation between adolescents with ADHD and OCD and healthy comparison adolescents
| Subject contrast | Brain regions of activation (Brodmann area; BA) | Talairach coordinates (x;y;z) | Voxels | Cluster P value |
|---|---|---|---|---|
| Stop–Go | ||||
| C > ADHD, OCD | R orbitofrontal/anterior cingulate (BA 11/10/47/32/24) | 18;52;−13 | 101 | 0.02 |
| Failed Stop–Go | ||||
| C, OCD > ADHD | R middle/inferior prefrontal (BA 44/45/9/46) | 51;22;20 | 22 | 0.027 |
| C > ADHD, OCD | L medial frontal/anterior cingulate (BA 8/9/32) | −14;33;26 | 29 | 0.027 |
| Switch–Repeat | ||||
| C > ADHD | R inferior frontal/insula/putamen/sup. temporal (BA 44/45/47/38) | 50;11; −2 | 47 | 0.01 |
| C > ADHD, OCDa | L inferior frontal/premotor/insula (BA 44/45/6) | −40;15;4 | 48 | 0.02 |
| C, OCD > ADHD | L putamen/caudate/anterior/posterior cingulate/parietal (BA 24/32/23/31/40) | −18;4;9 | 141 | 0.002 |
P‐value for ANOVAs is <0.05 for voxel activation and <0.03 for cluster activation. Those P‐values were selected to yield less than one false positive cluster per brain map.
a
Reduced in patients with OCD at a trend‐level.