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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Biomaterials. 2019 Oct 18;227:119558. doi: 10.1016/j.biomaterials.2019.119558

Figure 5: Comparative efficacy of the combination treatment vs. TXT-NPs alone.

Figure 5:

Animals with tumor received either DNmb + TXT-NPs (12 mg/kg TXT dose equivalent NPs + 3 mg/kg, DNmb) or TXT-NPs alone (12 mg/kg TXT dose equivalent). Arrows indicate treatment schedule. Changes in a) bioluminance signal in treatment groups vs. saline control; p<0.05 b) body weight, p= 0.01 for combination vs. saline group, combination vs. TXT-NPs, p=NS, and c) survival with time. Data are expressed as the mean ± s.e.m., n= 3 to 5. Blue (TXT-NPs) and green (combination) lines overlap each other. Treatments vs. saline control p= 0.001. Median survival for saline = 5 wks; > TXT-NP or DNmb + TXT-NP > 25 wks, which is beyond the study end point.