Table 1.
Summary of attributes and levels used in the DCE survey
| Test attribute | Possible levels for each testing alternative | |||
|---|---|---|---|---|
| Whole genome sequencing | Whole exome sequencing | Cardiac panel test | Genetic testing not indicated | |
| Ability of the test to identify pathogenic mutations | Pathogenic mutation is identified in 20 out of every 100 cases | Pathogenic mutation is identified in 0 out of every 100 cases | ||
| Pathogenic mutation is identified in 30 out of every 100 cases | ||||
| Pathogenic mutation is identified in 40 out of every 100 cases | ||||
| Pathogenic mutation is identified in 50 out of every 100 cases | ||||
| Ability of the test to identify variants of unknown significance | Variant of unknown significance is identified in 10 out of every 100 cases | Variant of unknown significance is identified in 0 out of every 100 cases | ||
| Variant of unknown significance is identified in 20 out of every 100 cases | ||||
| Variant of unknown significance is identified in 30 out of every 100 cases | ||||
| Test cost | £1000 | £500 | £150 | £0 |
| £3000 | £1500 | £300 | ||
| £5000 | £2500 | £450 | ||
| £7000 | £3500 | £600 | ||
| Quantity of counselling received | 40 min | 40 min | 10 min | 0 min |
| 50 min | 50 min | 20 min | ||
| 60 min | 60 min | 30 min | ||
| Disclosure of secondary findings | No secondary findings disclosed | No secondary findings disclosed | ||
| Subset of well-characterised secondary findings disclosed | ||||