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. Author manuscript; available in PMC: 2019 Nov 21.
Published in final edited form as: Biotarget. 2019 Oct 12;3:19. doi: 10.21037/biotarget.2019.09.01

Figure 2.

Figure 2

Schematic model of the mechanism of HuR-regulated tumor cell migration. Left panel, HuR stabilizes the mRNAs of cell-migration-associated genes via a uronic acid pathway-independent mechanism. Right panel, HuR reduces the SNAI1 mRNA degradation via a uronic acid pathway-dependent mechanism. Upon EGFR activation, phosphorylated UGDH converts UDP-Glc into UDP-GlcUA and release HuR to bind ARE and stabilize SNAI1 mRNA. Increased SNAI1 mRNA expression enhances the epithelial mesenchymal transition and promotes cancer metastasis. UGDH, UDP-glucose dehydrogenase; GlcUA, glucuronic acid; ARE, adenylate uridylate rich element; UDP, uridine diphosphate.