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. 2018 Oct 1;36(10):923–927. doi: 10.1038/nbt.4263

Table 2.

Patents on GFP initially aggregated and outlicensed by GE Healthcare

Patent No. Title Legal status Expiration date
US 5,491,084 Uses of green fluorescent protein Expired 2013-09-10
US 6,146,826 Green fluorescent protein Expired 2017-11-14

US 5,625,048

US 5,777,079

US 6,319,669

US 6,066,476

Modified green fluorescent proteins

Modified green fluorescent proteins

Modified green fluorescent proteins

Modified green fluorescent proteins

Expired

Expired

Expired

Expired

2014-11-10

2014-11-10

2014-11-10

2014-11-10

US 5,804,387

US 6,090,919

FACS-optimized mutants of the green fluorescent protein

FACS-optimized mutants of the green fluorescent protein

Expired

Expired

2016-02-01

2017-01-31

US 5,958,713 Method of detecting biologically active substances by using GFP Expired 2015-01-31
US 5,968,738 Two-reporter FACS analysis of mammalian cells using GFP Expired 2015-12-06
US 5,994,077 Fluorescence-based isolation of differentially induced genes Expired 2015-01-31

US 6,054,321

US 6,077,707

US 6,124,128

US 6,403,374

Long wavelength engineered fluorescent proteins

Long wavelength engineered fluorescent proteins

Long wavelength engineered fluorescent proteins

Long wavelength engineered fluorescent proteins

Expired

Expired

Expired

Expired

2016-08-16

2016-08-16

2016-08-16

2016-08-16

US 6,172,188

US 6,818,443

US 7,314,915

Novel fluorescent proteins

Novel fluorescent proteins

Novel fluorescent proteins

Expired

Expired

Expired

2015-09-22

2015-09-22

2015-09-22

CA 2232727 Novel variants of green fluorescent protein, GFP Expired 2016-01-31

EP 0804457

EP 0815257

EP 0851874

Modified green fluorescent proteins

A method of detecting biologically active substances

Novel variants of green fluorescent protein, GFP

Expired

Expired

Expired

2014-11-10

2016-01-31

2016-01-31

JP 3283523

JP 3535177

Modified green fluorescent protein

A new variant of a GFP is a green fluorescent protein

Expired

Expired

2015-11-13

2016-01-31