Table II.
Structural MRI findings from healthy controls, patients with amnestic mild cognitive impairment (aMCI), and patients with Alzheimer's disease (AD)
| Healthy controls | aMCI patients | AD patients | P * | |
|---|---|---|---|---|
| WMHs load (SD) [ml] | 3.52 (3.07) | 6.16 (11.02) | 4.64 (4.06) | n.s. |
| NBV (SD) [ml] | 1,438 (91) | 1,416 (99) | 1,335 (54) | 0.03 |
| Normalized GM volume (SD) [ml] | 747 (50) | 699 (88) | 656 (82) | 0.05 |
| Normalized cortical GM volume (SD) [ml] | 571 (45) | 530 (75) | 483 (62) | 0.02 |
| Normalized WM volume (SD) [ml] | 691 (59) | 716 (56) | 679 (84) | n.s. |
| R hippocampus volume (SD) [ml] | 5.1 (0.03) | 4.4 (0.04) | 4.1 (0.07) | 0.001 |
| L hippocampus volume (SD) [ml] | 5.1 (0.05) | 4.5 (0.05) | 4.2 (0.07) | 0.01 |
| GM average MD (SD) [×10−3 mm2 s−1] | 1.06 (0.09) | 1.14 (0.12) | 1.20 (0.11) | 0.01 |
| NAWM average MD (SD) [×10−3 mm2 s−1] | 0.83 (0.04) | 0.87 (0.06) | 0.91 (0.08) | 0.03 |
| NAWM average FA (SD) | 0.30 (0.02) | 0.28 (0.03) | 0.26 (0.03) | 0.02 |
Abbreviations: aMCI = amnestic mild cognitive impairment; AD = Alzheimer's disease; WMHs = white matter hyperintensities; SD = standard deviation; NBV = normalized brain volume; GM = grey matter; WM = white matter; R = right; L = left; MD = mean diffusivity; NAWM = normal‐appearing white matter; FA = fractional anisotropy.
*
Analysis of covariance (ANCOVA) between groups adjusted for age. See text for further details.