Table III.

Contrasts between insula sub‐regions in a random effects group analysis of connectivity

Contrast	Anatomical location (center of gravity)	Talairach coordinates			voxels
		x	y	z
LaIC >	Left anterior insula	−29	16	−1	15,644
LpIC	Left cingulate gyrus/BA 32 (aMCC)	−1	23	38	4,190
	Left caudate	−12	−4	18	506
	Left middle frontal gyrus/BA 46	−26	48	15	1,075
	Right anterior insula	40	18	6	5,063
	Right middle frontal gyrus/BA 9	37	23	28	223
	Right caudate	7	−5	13	2,132
LaIC >	Left anterior insula	−32	17	−4	2,501
LmIC	Left medial frontal gyrus/BA 9	−1	50	25	200
	Left cingulate/medial frontal gyrus/BA 32 (pACC/aMCC)	−8	45	18	306
	Left superior frontal gyrus/BA 9	−22	58	20	523
	Left inferior frontal gyrus/BA 47	−20	30	−7	171
	Right superior frontal gyrus/BA 10	21	63	2	148
LmIC >	Left mid–posterior insula	−38	−9	12	1,193
LaIC
LmIC >	Left mid‐insula	−20	5	13	34,221
LpIC	Left middle frontal gyrus/BA 9	−37	31	32	168
	Left supramarginal gyrus/BA 40	−56	−43	37	153
	Left inferior frontal gyrus/BA 47	−60	23	−13	245
	Right inferior parietal lobule/supramarginal gyrus/BA 40	54	−40	33	3,730
	Right inferior frontal gyrus/BA 45/45	40	21	15	14,981
	Right inferior parietal gyrus/BA 40	56	−39	50	128
	Right fusiform/inferior temporal gyrus/BA 37	46	−48	−12	167
	Right precentral gyrus/BA 4	36	−7	54	1,154
	Right precuneus/BA 7	10	−66	52	263
	Right cingulate gyrus/BA 32 (aMCC/pMCC)	1	11	40	2,872
RaIC >	Right anterior insula/inferior frontal gyrus/BA 45/44	31	32	6	24,900
RpIC	Right cingulate gyrus/BA 32 (aMCC)	3	24	37	334
	Right cingulate gyrus/BA 24 (pACC)	7	35	6	316
	Left anterior insula	−37	18	−3	1,627
	Left superior frontal gyrus/BA 9	−25	47	27	418
	Left middle frontal gyrus/BA 10	−32	46	−4	188
RaIC >	Right inferior frontal gyrus/BA 47	37	23	−6	649
RmIC
RmIC >	Right mid–posterior insula	38	−12	15	8,069
RaIC	Right paracentral/cingulate gyrus/BA 31 (pMCC/aPCC)	6	−20	45	752
	Left mid–posterior insula	−36	−16	12	4,872
	Left paracentral/cingulate gyrus/BA 31(pMCC/aPCC)	−10	−18	45	311
RmIC >	Right anterior mid‐insula	36	18	14	45,219
RpIC	Right middle frontal gyrus/BA 9	53	−38	33	8,999
	Right middle–inferior temporal gyrus/BA 21/20	46	−32	−14	1,589
	Right superior frontal gyrus/BA 6	20	−5	64	191
	Right cingulate gyrus/BA 32/24 (aMCC/pMCC)	1	4	44	1,319
	Left anterior mid‐insula	−40	5	8	13,289
	Left middle frontal gyrus/BA 46/9	−35	38	26	6,001
	Left inferior parietal lobule/BA 40	−56	−39	29	4,589
	Left inferior temporal gyrus/BA37	−57	−55	−5	749

Anatomical locations and center of gravity coordinates (in Talairach space) are provided for the brain areas where the strength of connectivity was found to be significantly different between insular sub‐regions at P < 0.05 (corrected). Voxels are reported as 1 × 1 × 1 mm³. aIC, anterior insula; mIC, mid‐insula; pIC, posterior insula; pACC, pregenual anterior cingulate cortex; aMCC, anterior mid‐cingulate cortex; pMCC, posterior mid‐cingulate cortex; S2, secondary somatosensory cortex; R, right; L, left.