Table III.
Significant paths coefficients (mean values and standard deviations) between brain regions of MS patients and controls in the entire study group and in the different centers
| Connection | Center | Connection strength control subjects (SD) | Connection strength MS patients(SD) | * P |
|---|---|---|---|---|
| L SMC—R Cerebellum | Total | 0.21 (0.06) | 0.19 (0.07) | 0.01 |
| Center 1 | 0.24 (0.06) | 0.20 (0.04) | ||
| Center 2 | 0.24 (0.04) | 0.23 (0.06) | ||
| Center 3 | 0.21 (0.05) | 0.16 (0.05) | ||
| Center 4 | 0.19 (0.05) | 0.14 (0.02) | ||
| Center 5 | 0.20 (0.06) | 0.17 (0.05) | ||
| Center 6 | 0.21 (0.05) | 0.19 (0.03) | ||
| Center 7 | 0.27 (0.06) | 0.24 (0.10) | ||
| Center 8 | 0.20 (0.04) | 0.17 (0.05) | ||
| L SMC—L PMd | Total | 0.10 (0.08) | 0.15 (0.07) | 0.009 |
| Center 1 | 0.06 (0.03) | 0.16 (0.08) | ||
| Center 2 | 0.07 (0.04) | 0.18 (0.07) | ||
| Center 3 | 0.11 (0.04) | 0.16 (0.09) | ||
| Center 4 | 0.17 (0.06) | 0.12 (0.06) | ||
| Center 5 | 0.13 (0.09) | 0.14 (0.03) | ||
| Center 6 | 0.10 (0.04) | 0.17 (0.11) | ||
| Center 7 | 0.12 (0.05) | 0.13 (0.07) | ||
| Center 8 | 0.03 (0.07) | 0.13 (0.09) | ||
| L PMd—SMA | Total | 0.05 (0.04) | 0.08 (0.05) | 0.002 |
| Center 1 | 0.01 (0.03) | 0.07 (0.03) | ||
| Center 2 | 0.05 (0.05) | 0.07 (0.04) | ||
| Center 3 | 0.04 (0.01) | 0.08 (0.07) | ||
| Center 4 | 0.07 (0.03) | 0.11 (0.08) | ||
| Center 5 | 0.07 (0.06) | 0.14 (0.07) | ||
| Center 6 | 0.05 (0.04) | 0.05 (0.02) | ||
| Center 7 | 0.04 (0.04) | 0.05 (0.04) | ||
| Center 8 | 0.02 (0.04) | 0.06 (0.05) | ||
| L SII—SMA | Total | 0.08 (0.04) | 0.10 (0.05) | 0.01 |
| Center 1 | 0.05 (0.02) | 0.10 (0.01) | ||
| Center 2 | 0.08 (0.04) | 0.11 (0.04) | ||
| Center 3 | 0.07 (0.02) | 0.09 (0.05) | ||
| Center 4 | 0.09 (0.05) | 0.12 (0.06) | ||
| Center 5 | 0.11 (0.06) | 0.14 (0.06) | ||
| Center 6 | 0.07 (0.03) | 0.08 (0.02) | ||
| Center 7 | 0.07 (0.04) | 0.09 (0.05) | ||
| Center 8 | 0.08 (0.03) | 0.08 (0.05) | ||
| SMA—L PMd | Total | 0.04 (0.05) | 0.08 (0.07) | 0.0009 |
| Center 1 | 0.01 (0.05) | 0.06 (0.04) | ||
| Center 2 | 0.02 (0.06) | 0.04 (0.04) | ||
| Center 3 | 0.05 (0.03) | 0.10 (0.08) | ||
| Center 4 | 0.08 (0.02) | 0.15 (0.06) | ||
| Center 5 | 0.09 (0.06) | 0.15 (0.08) | ||
| Center 6 | 0.05 (0.04) | 0.03 (0.04) | ||
| Center 7 | 0.03 (0.02) | 0.06 (0.03) | ||
| Center 8 | 0.01 (0.04) | 0.06 (0.04) | ||
| SMA—L SII | Total | 0.08 (0.04) | 0.11 (0.05) | 0.03 |
| Center 1 | 0.07 (0.03) | 0.09 (0.03) | ||
| Center 2 | 0.09 (0.04) | 0.09 (0.05) | ||
| Center 3 | 0.09 (0.02) | 0.10 (0.05) | ||
| Center 4 | 0.08 (0.06) | 0.12 (0.08) | ||
| Center 5 | 0.12 (0.05) | 0.13 (0.05) | ||
| Center 6 | 0.07 (0.02) | 0.09 (0.04) | ||
| Center 7 | 0.07 (0.03) | 0.12 (0.05) | ||
| Center 8 | 0.08 (0.04) | 0.10 (0.04) | ||
| R SII—SMA | Total | 0.07 (0.04) | 0.09 (0.05) | 0.006 |
| Center 1 | 0.05 (0.03) | 0.07 (0.01) | ||
| Center 2 | 0.08 (0.04) | 0.10 (0.04) | ||
| Center 3 | 0.05 (0.02) | 0.08 (0.04) | ||
| Center 4 | 0.08 (0.04) | 0.11 (0.06) | ||
| Center 5 | 0.10 (0.07) | 0.13 (0.06) | ||
| Center 6 | 0.05 (0.03) | 0.07 (0.02) | ||
| Center 7 | 0.06 (0.03) | 0.09 (0.06) | ||
| Center 8 | 0.07 (0.04) | 0.08 (0.04) | ||
| SMA—R SII | Total | 0.08 (0.05) | 0.10 (0.05) | 0.03 |
| Center 1 | 0.08 (0.03) | 0.09 (0.02) | ||
| Center 2 | 0.08 (0.04) | 0.10 (0.06) | ||
| Center 3 | 0.07 (0.02) | 0.09 (0.04) | ||
| Center 4 | 0.09 (0.06) | 0.13 (0.05) | ||
| Center 5 | 0.11 (0.06) | 0.12 (0.05) | ||
| Center 6 | 0.06 (0.05) | 0.08 (0.03) | ||
| Center 7 | 0.07 (0.03) | 0.11 (0.05) | ||
| Center 8 | 0.08 (0.04) | 0.10 (0.04) | ||
| L SII—R SII | Total | 0.07 (0.04) | 0.09 (0.04) | 0.03 |
| Center 1 | 0.06 (0.03) | 0.08 (0.02) | ||
| Center 2 | 0.07 (0.03) | 0.08 (0.05) | ||
| Center 3 | 0.06 (0.02) | 0.09 (0.05) | ||
| Center 4 | 0.08 (0.05) | 0.10 (0.05) | ||
| Center 5 | 0.09 (0.05) | 0.09 (0.04) | ||
| Center 6 | 0.05 (0.03) | 0.07 (0.02) | ||
| Center 7 | 0.06 (0.02) | 0.13 (0.05) | ||
| Center 8 | 0.06 (0.02) | 0.07 (0.04) | ||
| R SMC—SMA | Total | 0.07 (0.04) | 0.09 (0.05) | 0.03 |
| Center 1 | 0.05 (0.02) | 0.08 (0.03) | ||
| Center 2 | 0.09 (0.06) | 0.10 (0.04) | ||
| Center 3 | 0.06 (0.02) | 0.07 (0.06) | ||
| Center 4 | 0.08 (0.03) | 0.13 (0.07) | ||
| Center 5 | 0.10 (0.05) | 0.13 (0.06) | ||
| Center 6 | 0.06 (0.04) | 0.07 (0.04) | ||
| Center 7 | 0.05 (0.04) | 0.08 (0.05) | ||
| Center 8 | 0.08 (0.04) | 0.09 (0.05) |
Only connections significantly different between controls and MS patients have been reported.
L, left; R, right; SMC, primary sensorimotor cortex; PMd, dorsal prefrontal cortex; SMA, supplementary motor area; SII, secondary sensorimotor cortex.
*
ANOVA, adjusted for center effect and age and adjusted for multiple comparisons.