Table I.

Comparing brain activation of men and women during sexual genital stimulation

Side	Brain regions	BA	Voxels	x	y	z	t
Common activations for men and women
L	Inferior parietal lobule (SII)	40	142	−54	−22	28	3.84
L	Postcentral gyrus (SI)	3	40	−20	−38	64	3.69
Common deactivations for men and women
R	Amygdala	−	379	20	−2	−24	4.88a , b
R	Fusiform gyrus	20	75	40	−20	−32	4.29
L	Fusiform gyrus	20	526	−54	−32	−28	4.06b
R	Middle temporal gyrus	21	68	54	10	−20	3.72
L	Inferior temporal gyrus	37	24	−56	−62	−16	3.57
Men > women
R	Claustrum	–	121	32	−18	−4	4.61a , b
L	Cerebellar vermis, posterior lobe	–	56	−10	−80	−16	4.11
R	Middle temporal gyus (VOT)	37	82	58	−64	−2	4.07b
L	Cerebellar vermis, Posterior lobe	–	101	−12	−82	−36	3.70
Women > men
L	Inferior parietal lobule (posterior parietal cortex)	40	367	−34	−56	44	4.90a
L	Postcentral gyrus (somatosensory area 2)	2	349	−52	−24	40	4.64a , b
L	Precentral gyrus/middle frontal gyrus (MI/PMC)	4/6	484	−40	−24	62	4.54a
R	Middle frontal gyrus (PMC)	6	210	30	6	64	4.35c
R	Middle frontal gyrus (PMC)	6	121	4	−8	52	4.01
R	Inferior parietal lobule (posterior parietal cortex)	40	26	48	−70	40	3.48c
L	Precuneus	7	21	−20	−74	46	3.37

Within‐gender, brain activation during sexual genital stimulation was compared to brain activation of a non‐sexual passive resting state (STIM vs. REST). Gender commonalities were found by conjunction and gender differences by mutual subtraction of these within‐gender T contrasts. The statistical threshold for brain regions listed in the table is P < 0.001, uncorrected for multiple comparisons (t = 3.15). Coordinates refer to the MNI (Montréal Neurological Institute) coordinate system.

^aCluster with peak voxel value of P _FWE < 0.05.

^bRegion included in a priori hypothesis.

^cRegion symmetrical to contralateral region with P _FWE < 0.05.

BA, Brodmann's area; P _FWE, family‐wise error corrected for multiple comparisons; L, left hemisphere; PMC, premotor cortex; R, right hemisphere; t, t value; SII, secondary somatosensory cortex; VOT, ventral occipitotemporal cortex; x, distance (mm) relative to midsagittal plane (+, right; −, left); y, distance (mm) relative to anterior commissure (+, anterior; −, posterior); z, distance (mm) relative to intercommissural line (+, dorsal; −, ventral).