Figure 2.

Analysis of natural products isolated from Burkholderia sensu lato. (A) Pie chart depicting biosynthetic class. Compounds belonging to the same structural class (defined as known or expected to be encoded in the same or very similar BGC) were counted as one. The 66 structural classes (corresponding to 66 cells in Figure 3) were then classified into seven biosynthetic classes as shown. Compounds that did not belong to any of the seven classes or for which the biosynthesis was unknown were classified as “other/unknown”. (B) Natural product identification method. “Other” includes structure-guided isolation. (C) Reported bioactivity. If a compound displayed more than one bioactivity, they were categorized as follows: Cytotoxic compounds that had more than one bioactivity were counted as “cytotoxic” only. Antitumor and anticancer compounds were also included under cytotoxic. Compounds that had antifungal and antibacterial activity were added to one of the two categories based on highest displayed potency. Activities that did not fit within the depicted groups were designated as “other”, which includes phosphodiesterase 4 inhibitor, Gq-signaling inhibitor, vasopressin and serotonin receptor interacting, plant growth inhibitor, ethylene biosynthesis inhibitor, virulence, and quorum sensing signal.