Table III.
Results of the DTI analysis of the HSP group (patients versus controls)
| Cluster | MNI coordinates of maximum (mm) | Hemisphere (R = right; L = left) | Level of significance Z‐score | Cluster size (number of voxels) n | Anatomical localization (white matter) | ||
|---|---|---|---|---|---|---|---|
| x | y | z | |||||
| Motor system | |||||||
| 1 | 20 | −25 | 49 | R + L | 5.6 | 39,667 | CST, CC |
| 2 | 26 | 18 | −5 | R | 5.7 | 3,568 | Capsula extrema |
| 3 | −3 | −25 | −8 | L | 5.1 | 1,252 | Brain stem (mesencephalon) |
| Limbic system and projectional fibers | |||||||
| 4 | −24 | 12 | −11 | L | 5.0 | 1,628 | Corpus amygdaloideum |
| 5 | 17 | −23 | −15 | R | 5.4 | 1,083 | Adjacent to the cingulate gyrus |
| 6 | −20 | −45 | 54 | L | 5.3 | 739 | Adjacent to the precuneus |
| 7 | −44 | −21 | −8 | L | 4.7 | 408 | Parahippocampal lobe |
| 8 | 34 | −6 | −16 | R | 5.4 | 306 | Fasciculus uncinatus |
| 9 | 32 | 11 | 30 | R | 5.3 | 157 | Adjacent to the middle/inferior frontal gyrus |
Results of the DTI analysis of the HSP group in comparison to the controls: areas of significant FA reduction, thresholded at P < 0.05 (FDR corrected). For levels of significance, anatomical localizations and abbreviations, cf. Table 2.