Table I.

Talairach coordinates of maximum relative changes in rCBF at 10 and 30 min after intravenous administration of methylphenidate (0.25 mg/kg)

Brain region	Cluster		Peak voxel	Talairach coordinates
	Size	P	T	x	y	z
MP > placebo t = 10 min
Anterior cingulate	1277	< 0.001	9.09	−4	37	2
Right temporal pole*	710	< 0.001	7.94	52	0	−39
Left temporal pole*	652	< 0.001	8.11	−57	6	−29
Supplementary motor area	251	0.01	6.94	−4	26	54
MP > placebo t = 30 min
Anterior cingulate	220	0.019	6.35	2	37	6
Left temporal pole*	280	0.006	6.18	−57	6	−29
Right cerebellum	321	0.003	6.68	40	−71	−22
Placebo > MP t = 10 min
Right superiortemporal gyrus	687	< 0.001	7.14	40	1	−19
Left superior temporal gyrus	202	0.028	5.51	−40	−8	−8
Right medial frontal gyrus	338	0.002	5.33	30	66	−10
Right medial frontal gyrus	183	0.041	5.03	32	50	20
Right inferior parietal cortex	209	0.024	4.90	55	−32	24

^*Activation in the temporal poles extends outside the brain and is therefore questionable.