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. 2019 Nov 14;3:155. Originally published 2018 Dec 6. [Version 2] doi: 10.12688/wellcomeopenres.14909.2

Table 6. Severity grading for adverse events.

Grading Definition
Grade 0 None
Grade 1 Mild: Transient or mild limitation in activity (<48 hours); no medical intervention/therapy required
Grade 2 Moderate: Mild to moderate limitation in activity - some assistance may be needed; no or minimal
medical intervention/therapy required
Grade 3 Severe: Marked limitation in activity, some assistance usually required; medical intervention/
therapy required, hospitalisation possible