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. 2019 Jul 11;27(11):1745–1756. doi: 10.1038/s41431-019-0468-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Heatmap of the proportion of SNPs showing opposite directional β-values. For each tissue pair, SNPs showing significant eQTL signals in both tissues were extracted. Direction of the β-values (effect sizes) of the SNPs was compared in each tissue pair, and proportion (%) of the SNPs that showed opposite directional β-values is shown by heatmap with the color scale shown on the top (blue to red). Plots of β-values of the SNPs in the two representative tissue pairs are shown on the bottom: A visceral adipose (ADPVSC) vs. breast (BREAST) and B whole blood (WHLBLD) vs. testis (TESTIS). SNPs with the same directional β-values are indicated as blue points, and SNPs with the opposite directional β-values are indicated as red points. There were no opposite eQTL effects found between ADPVSC and BREAST, while the largest proportion (10.7%) of the opposite eQTL effects were detected between WHLBLD and TESTIS