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. 2019 Jul 11;27(11):1745–1756. doi: 10.1038/s41431-019-0468-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Distribution of the distance from TSS in each type of SNPs. For each type of SNPs (SNPs with any eQTL signal, top-eQTL-, multi-eQTL-, and opp-multi-eQTL-SNPs), the distribution of the distance from TSS is shown (in light blue, dark blue, green, and red, respectively). To adjust the number of sharing tissues of multi-eQTL-SNPs to that of opp-multi-eQTL-SNPs, subset of the multi-eQTL-SNPs was also analyzed, which is shown in an orange line. The TSS enrichment was evaluated on kurtosis of the density plot, and its significance level in opp-multi-eQTL-SNPs compared to adjusted multi-eQTL-SNPs was p < 1.0 × 10⁻⁴, which was determined by 10,000-time random sampling