Table 2.

Aligned amino acid sequences at each missense variant position

Case	1	2	3	4	5	6	7	8
Position	20	48	119	147	188	188	188	697
New amino acid	Q	V	E	K	C	H	H	Q
Orthologs
Human	E	L	K	E	R	R	R	R
Chimp	E	L	K	E	R	R	R	R
Olive baboon	E	L	K	E	R	R	R	R
Rat	E	L	K	E	R	R	R	R
Mouse	E	L	K	E	R	R	R	R
Dog	E	L	K	E	R	R	R	R
Frog	E	L	K	E	R	R	R	R
Tetraodon	E	L	K	E	R	R	R	R
Zebrafish	E	L	K	E	R	R	R	R
Fruitfly	E	L	R	E	R	R	R	R
C. elegans	E	L	K	E	R	R	R	R
Baker’s yeast	E	L	R	D	R	R	R	K