Table 4.
Comparison of diagnostic performance of index tests—any risk
| SENS | SPEC | PPV | NPV | FPR | ACC | ||
|---|---|---|---|---|---|---|---|
| T13 | |||||||
| Proton™ | 6/6 | 3408/3418 | 6/16 | 3408/3408 | 10/3418 | 3414/3424 | |
| HiSeq™ | 7/7 | 3440/3447 | 7/14 | 3440/3440 | 7/3447 | 3447/3454 | |
| p value | — | 0.456 | 0.491 | — | 0.456 | 0.455 | |
| T18 | |||||||
| Proton™ | 48/48 | 3368/3376 | 48/56 | 3368/3368 | 8/3376 | 3416/3424 | |
| HiSeq™ | 49/49 | 3397/3405 | 49/57 | 3397/3397 | 8/3405 | 3446/3454 | |
| p value | — | 0.986 | 0.970 | — | 0.986 | 0.986 | |
| T21 | |||||||
| Proton™ | 150/152 | 3265/3272 | 150/157 | 3265/3267 | 7/3272 | 3415/3424 | |
| HiSeq™ | 151/152 | 3295/3302 | 151/158 | 3295/3296 | 7/3302 | 3446/3454 | |
| p value | 1.000 | 0.986 | 0.990 | 0.623 | 0.986 | 0.794 | |
| 45,X | |||||||
| Proton™ | 18/21 | 3375/3403 | 18/46 | 3375/3378 | 28/3403 | 3393/3424 | |
| HiSeq™ | 15/21 | 3421/3433 | 15/27 | 3421/3427 | 12/3433 | 3436/3454 | |
| p value | 0.454 | 0.0103 | 0.173 | 0.508 | 0.0103 | 0.058 | |
| Any of T13, T18, or T21 | |||||||
| Proton™ | 204/206 | 3193/3218 | 204/229 | 3193/3195 | 25/3218 | 3397/3424 | |
| HiSeq™ | 207/208 | 3224/3246 | 207/229 | 3224/3225 | 22/3246 | 3431/3454 | |
| p value | 0.622 | 0.639 | 0.644 | 0. 623 | 0.639 | 0.549 |
Comparison of the two index tests in all samples tested (any risk) for fetal T13, T18, T21, Turner syndrome and any of T13, T18, or T21 (rows). For each fetal anomaly index tests are compared for clinical sensitivity (SENS), clinical specificity (SPEC), positive predictive value (PPV), negative predictive value (NPV), false positive rate (FPR), and clinical accuracy (ACC). Absolute ratios are presented with the p value of the Chi-Square or Fisher’s exact test statistics, depending on the number of results available