Table 2.

Comparison of Merkel cell carcinoma lesion dosimetry for patients A and B.^a

Patientb	NRT dose (Gy)				Equivalent XRT dosec (Gy)
	n	Total	Fraction size	RBEc	Total	Fraction Size	EQD2
In-field dosimetry
*	1	2.52	2.52	3.2	8.00	8.00	17.6
*	1	10.58	10.58	2.8	30.00	30.00	198.0
A	2	6.00	3.00	3.1	18.67	9.34	46.1
*	3	7.57	2.52	3.2	24.00	8.00	52.8
B	8	16.00	2.00	3.3	52.22	6.53	99.5
B	10	18.00	1.80	3.3	59.56	5.96	106.7
*	10	8.04	0.80	3.7	30.00	3.00	36.0
B	12	18.00	1.50	3.4	61.07	5.09	98.8
*	16	18.40	1.15	3.5	64.91	4.06	91.6
Out-of-field dosimetry
A	2	0.32	0.16	4.7	1.51	0.75	1.1
A	2	0.44	0.22	4.5	1.99	1.00	1.6
A	2	1.00	0.50	4.0	4.02	2.01	4.0
A	2	1.98	0.99	3.6	7.15	3.57	9.4

Abbreviations: NRT, neutron radiation therapy; RBE, relative biological effectiveness; XRT, x-ray radiation therapy; EQD2, equivalent dose at 2 Gy.

^aPatient A was treated with 2 × 3 neutron-Gy (in-field), and patient B was treated with 8 to 12 fractions for a total of 16 to 18 Gy.

^bTo provide additional clinical context, equivalent XRT and NRT doses are also listed for alternative treatment schedules (Patient *).

^cEstimates of neutron RBE and equivalent XRT dose are for (α/β) = 3 Gy.