Figure 5.

(A) Experiment 1: Cellular survival curves measured for LN229 cells treated with 150 MeV protons in mid–spread-out Bragg peak and with 6 MV Linac photons. (B) Experiment 2: Dose-dependent clonogenic survival obtained after treatment with 150 MeV mid–spread-out Bragg peak protons alone (open squares) and in combination with (B) Experiment 2: Dose-dependent clonogenic survival obtained after treatment with 150 MeV mid-SOBP protons alone (open squares) and in combination with TMZ (filled symbols). The dose response curves for combined treatment are shown twice: normalized to the unirradiated control k₂ (filled squares) and additionally multiplied by the ratio of the averaged k₁ and k₂ (filled dots). The plotted survival fraction values are shown with their corresponding standard error of the mean.