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Clinical target volume percentage change from baseline volume versus time (in days) since proton beam therapy. Color key: red, pure responders (R); pink, pseudoprogression (PP); blue, nonresponders (NR). Abbreviations: Δshunt, shunt revision; +chemo, chemotherapy; ALL, acute lymphoblastic leukemia; O2, hyperbaric oxygen; PD, progressive disease; PR, partial response.
