Table 1.
Patient No. |
Age at diagnosis, y |
Sex |
Stage |
RT prescription dose, Gy (RBE) |
Cumulative anthracycline dose, mg/m2 |
Mean heart RT dose, Gy (RBE) |
Mean LAD RT dose, Gy (RBE) |
Mean LV RT dose, Gy (RBE) |
Mean RV RT dose, Gy (RBE) |
Pretherapy LVEF TTE, % |
LVEF on 5-y cardiac MRI, % |
LVEF on 5-y TTE, % |
5-y Pro-BNP, pg/mL |
1 | 19 | F | IIB | 39.6a | 350 | 19.7 | 32.2 | 10.1 | 27.9 | 60 | 53 | 50 | 182.4 |
2 | 25 | F | IIB | 36 | 300 | 13.8 | 33.4 | 20.1 | 12.4 | 72 | 61 | 60-65 | 95.4 |
3 | 40 | F | IIB | 30.6 | 175 | 2.1 | 9.0 | 0.1 | 0.5 | 54b | 60 | 60-65 | 120.0c |
4 | 37 | M | IIB | 36 | 200 | 10.1 | 2.9 | 2.1 | 3.4 | 51 | 52 | 55-60 | 29.1 |
5 | 22 | M | IB | 30.6 | 300 | 7.6 | 4.6 | 0.0 | 14.4 | 59d | 54 | 50-55 | 22.0 |
Abbreviations: RT, radiotherapy; RBE, relative biological effectiveness; LAD, left anterior descending artery; LV, left ventricle; RV, right ventricle; LVEF, left ventricular ejection fraction; TTE, transthoracic echocardiogram; MRI, magnetic resonance imaging; BNP, brain natriuretic peptide; ABVD, doxorubicin, bleomycin, vinblastine, dacarbazine.
Treated with deep inspiration breath hold.
After third cycle of ABVD.
Drawn 6 y after treatment completion.
After sixth cycle of ABVD.