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. Author manuscript; available in PMC: 2019 Nov 21.
Published in final edited form as: Aliment Pharmacol Ther. 2009 Apr 8;30(1):37–47. doi: 10.1111/j.1365-2036.2009.04014.x

Table 4.

Sensitivity of ultrasound with or without alpha-fetoprotein for the detection of early-stage HCC

First author and study No. pts No. HCC No. early HCC Ultrasound sensitivity (95% CI) Ultrasound with AFP sensitivity (95% CI)
Kobayashi33 95 8 6 0.5 (0.16–0.84) 0.50 (0.16–0.84)
Arrigoni28 164 16 12 0.69 (0.41–0.89) 0.75 (0.48–0.93)
Oka31 140 40 33 0.68 (0.51–0.81) 0.8 (0.64–0.91)
Pateron34 118 14 5 0.23 (0.05–0.54) 0.38 (0.14–0.68)
Cottone29 147 5 4 0.87 (0.69–0.96) 0.87 (0.69–0.96)
Zoli32 164 34 32 0.91 (0.76–0.98) 0.91 (0.76–0.98)
Tradati45 40 6 2 0.33 (0.04–0.78) 0.33 (0.04–0.78)
Henrion30 94 6 6 0.67 (0.22–0.96) 1.0 (0.54–1.0)
Bolondi42 313 61 50 0.82 (0.70–0.91) 0.82 (0.70–0.91)
Caturelli27 1599 269 264 0.98 (0.96–0.99) 0.99 (0.96–0.99)
Santagostino46 66 8 2 0.25 (0.03–0.65) 0.25 (0.03–0.65)
Sangiovanni43 417 112 55 0.50 (0.41–0.60) 0.50 (0.41–0.60)
Sangiovanni44 214 68 34 0.50 (0.38–0.62) 0.50 (0.38–0.62)
Pooled estimates 3113 498 434 0.69 (0.50–0.83) 0.74 (0.56–0.87)
Pooled estimates* 1514 229 170 0.63 (0.49–0.76) 0.69 (0.53–0.81)

Pts, patients; HCC, hepatocellular carcinoma; AFP, alpha-fetoprotein.

*

Pooled estimates after exclusion of outlier studies (Caturelli et al.27).