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The homeostatic model of mRNA decay-transcription feedback proposes that appropriate mRNA levels are maintained by either altering mRNA decay or Pol II transcription. Removal of basal RNA decay factors results in decreased mRNA decay and stabilization of mRNAs; transcription then decreases to buffer against resulting increases in mRNA levels. Similarly, perturbations that cause reductions in transcription and thus less mRNA production are buffered through stabilization of mRNA.
