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. Author manuscript; available in PMC: 2020 Oct 27.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2019 Oct 27;54(4):385–398. doi: 10.1080/10409238.2019.1679083

Figure 5.

Figure 5.

mRNA coordinators Rpb4/7 are implicated in imprinting mRNAs in the nucleus to convey transcription rate to the cytoplasm. Rpb4/7 have been shown to interact with the nascent mRNA chain in the nucleus and Pat1 and members of the Lsm1–7 complex in the cytoplasm. RNA decay factors Ccr4-Not and Xrn1 degrade mRNA in the cytoplasm and may affect Pol II elongation by either coordinating with (Ccr4-Not) or antagonizing (Xrn1) the Pol II co-factor TFIIS, which is responsible for disengaging stalled Pol II.