Skip to main content
. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: J Immunol. 2019 Dec 1;203(11):2757–2769. doi: 10.4049/jimmunol.1900901

Figure 3. Inflammasomes in placental inflammation.

Figure 3.

Endothelial-derived extracellular vesicles and/or alarmins (e.g. cholesterol or uric acid) can activate the NLRP3, NLRP1, and NLRP7 inflammasomes in the placenta, leading to the processing and release of active caspase-1 and mature IL-1β. The resulting inflammation may lead to placental diseases such as preeclampsia and fetal growth restriction.