Figure 2.

Multi‐subject analysis of BOLD signal fluctuations during rest with eyes closed. A binary mask for each subject was created by thresholding the individual F‐contrast images at F > 1.69 (P < 0.001 uncorrected). A final binary mask image showing voxels in the brain exhibiting low‐frequency fluctuations in all subjects at the specified statistical threshold was constructed by multiplying together all the individual binary mask images. Voxels that met these criteria are depicted in red and superimposed on a T1‐weighted high‐resolution MR image of one subject in the study. Spontaneous, low frequency BOLD signal changes at a multi‐subject level are observed in the prefrontal cortex with clusters centered foremost in the medial PFC and bilaterally in the dorsolateral cortices. Extensive areas of activity are present in the parietal cortex bilaterally and the precuneus and PCC.