Figure 2.

Volume rendering of between‐group contrasts where relative increased activity for healthy subjects is presented in red‐yellow (DLPFC; BA9) and relative increased activity for patients with schizophrenia is shown in purple‐pink (anterior cingulate; BA32). Although patients with schizophrenia engaged the DLPFC less than comparison subjects, they overactivated a portion of the anterior cingulate. Evidence of reduced DLPFC activation and increased activity in the anterior cingulate may be consistent with the notion that schizophrenia disrupts or reverses the normal functional connectivity of prefrontal and limbic structures.