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. 2019 Nov 21;15(11):e1008008. doi: 10.1371/journal.ppat.1008008

Fig 1. Mitochondrial dynamics.

Fig 1

Mitochondria of animals and fungi undergo constant cycles of opposing fission and fusion events. For division, the molecules of DRP are recruited to the mitochondrial surface by DRP receptors. The sites of membrane fission often coincide with the ER-mitochondria connections. Membrane-anchored DRPs specific for the outer (Mfn1,2/Fzo1) and the inner (Opa1/Mgm1) mitochondrial membrane mediate the fusion. Defective mitochondria are removed from the cycle by mitophagy. DRP, dynamin-related proteins; ER, endoplasmic reticulum.