Table 1. Distribution of components involved in mitochondrial division and fusion in parasitic protists.
Drp1/ Dnm1 | Drp1/Dnm1 receptors | Fusion | Mitofusin | ERMES | Mitophagy | |||
---|---|---|---|---|---|---|---|---|
Species | Fis1 | Mff MiD51 MiD49 | Caf4 Mdv1 | |||||
Plasmodium falciparum | 32–34 | 35 | ||||||
T. gondii | 34,40,42 | 42 | 45,46 | |||||
Cryptosporidium sp. | 98 | |||||||
T. brucei | 56,58,89 | 56,58,59 | 63? | 60? | 83,99,100# | |||
Leishmania sp. | 58 | 83 | 101 | |||||
T. vaginalis | 74 | 102 | ||||||
G. intestinalis | 78,81,82 | |||||||
E. histolytica | 87,88 | 89? |
White fields depict the presence of the orthologous protein; references to corresponding publications are shown. The phenotypic observation of mitochondrial fusion or mitophagy is also marked. Question mark depicts the indirect evidence.
#Homologues of ERMES components present but neither form a complex nor participate in the ER-mitochondrion contact sites.
Abbreviation: ERMES, ER-mitochondria encounter structure