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. 2019 Nov 21;15(11):e1008008. doi: 10.1371/journal.ppat.1008008

Table 1. Distribution of components involved in mitochondrial division and fusion in parasitic protists.

Drp1/ Dnm1 Drp1/Dnm1 receptors Fusion Mitofusin ERMES Mitophagy
Species Fis1 Mff MiD51 MiD49 Caf4 Mdv1
Plasmodium falciparum 32–34 35
T. gondii 34,40,42 42 45,46
Cryptosporidium sp. 98
T. brucei 56,58,89 56,58,59 63? 60? 83,99,100#
Leishmania sp. 58 83 101
T. vaginalis 74 102
G. intestinalis 78,81,82
E. histolytica 87,88 89?

White fields depict the presence of the orthologous protein; references to corresponding publications are shown. The phenotypic observation of mitochondrial fusion or mitophagy is also marked. Question mark depicts the indirect evidence.

#Homologues of ERMES components present but neither form a complex nor participate in the ER-mitochondrion contact sites.

Abbreviation: ERMES, ER-mitochondria encounter structure