Table II.

Signal decreases in limbic and subcortical gray structures during acupuncture at LI 4

Anatomic region	Left LI 4 (n = 5)						Right LI 4 (n = 7)
	Talairach cor			P value KS Stat.	Signal change % (max voxel)	Proportion of individuals*	Talairach cor			P value KS Stat.	Signal change % (max voxel)	Proportion of indivduals
	R‐L	A‐P	S‐I				R‐L	A‐P	S‐I
N accumbens/	3	9	−3	7.2 × 10−9	−0.46	4/6	5/7
septi	−9	9	0	3.4 × 10−11	−0.43	5/6	−12	9	3	5 × 10−6	−0.23	6/7
Amygdala	18	−6	−12	8.9 × 10−6	−0.24	4/6	15	−6	−9	7.6 × 10−11	−0.56	5/7
	−15	−6	−21	2.7 × 10−6	−0.45	4/6	−28	−3	−15	1.5 × 10−11	−0.66	7/7
Hippocampus	34	−15	−15	2.2 × 10−7	−0.28	5/6	25	−15	12	3.4 × 10−11	−0.30	7/7
−25	−15	−15	2.2 × 10−7	−0.26	4/6	−21	−15	−12	1.5 × 10−8	−0.47	6/7
Parahippocampus	25	−21	−15	2.7 × 10−5	−0.18	5/6	31	−12	−25	5.9 × 10−8	−0.32	7/7
	−28	−21	−21	7.9 × 10−5	−0.2	5/6	−28	−9	−25	1.5 × 10−6	−0.35	6/7
Hypothalamus	6	0	−3	−7.9 × 10−5	−0.27	3/6	6	−9	−6	−9.0 × 10−4	−0.17	4/7
	−9	0	−3	−2.2 × 10−7	−0.32	4/6	−6	−6	−3	−7.2 × 10−9	−0.45	4/7
Ventral tegmental area	12	−21	0	−4.3 × 10−7	−0.17	3/6	9	−18	−12	−1.2 × 10−7	−0.22	4/7
							−9	−12	−3	−7.2 × 10−9	−0.24	5/7
Ant. cingulate G	6	3	34	7.2 × 10−9	−0.29	5/6	12	0	37	2.7 × 10−6	−0.18	4/7
	−3	3	37	2.7 × 10−5	−0.2	5/6	−6	0	31	3.5 × 10−9	−0.15	5/7
Caudate N	9	12	3	1.7 × 10−12	−0.33	5/6	9	15	6	8.9 × 10−6	−0.24	4/7
	−15	15	3	3.5 × 10−10	−0.32	5/6	−21	18	0	1.7 × 10−9	−0.25	4/7
Putamen	15	12	−3	3.0 × 10−8	−0.34	4/6	15	15	3	1.2 × 10−7	−0.31	4/7
	−15	12	0	2.2 × 10−7	−0.30	4/6
Ant. insula	31	18	0	3.5 × 10−9	−0.25	4/6	28	15	6	5.0 × 10−6	−0.19	4/7
	−31	12	3	4.3 × 10−7	−0.17	4/6	−25	18	−3	1.2 × 10−7	−0.21	4/7
Temporal pole	40	15	−12	3.5 × 10−9	−0.32	5/6	50	12	−21	3.6 × 10−10	−0.48	5/7
	−50	6	−18	7.6 × 10−11	−0.26	4/6	−34	15	−21	3.5 × 10−9	−0.62	6/7

^*Subject with a shorter interval between needling could not be included in the group average, but was included in the individual data analysis.