Table I.

Brain areas of statistically significant change between pairs of experimental conditions for both PET and LORETA

Region	PET			P	Region	Band	LORETA			P
	x	y	z				x	y	z
Placebo/control task vs. MDMA/control task
Plac < MDMA
L Orbitofrontal (B11)	−18	26	−16	0.05	Whole brain, except central frontal, posterior cingulate, mediodorsal prefrontal	β2				0.02a
R Occipital (B31)	20	−72	28	0.009	Whole brain, except central frontal, posterior cingulate, parietal, left temporoo‐ccipital, right fusiform	β3				0.03a
L Inferior occipital (B18)	−20	−84	−8	0.05
L Occipital (B17)	−12	−88	4	0.05
Plac > MDMA
R Insula (B13)	50	10	4	0.001	L Parietal supramarginal (B40)	β3				0.03a
L Amygdala/L Cingulate (B34)	−14	−2	−12	0.03
R Paracentral lobule (B31)	2	−26	44	0.004
Anterior cingulate (B24)	0	2	32	0.004
L Anterior cingulate (B24)	−4	8	28	0.006
R Anterior cingulate (B32)	4	8	40	0.006
Posterior cingulate (B31)	0	−28	36	0.007	Posterior Cingulate (B31/23)	β2				0.02 a
R Superior frontal (B6)	10	−12	−64	0.05
R Anterior cingulate (B24)	2	−8	36	0.05
Placebo/CPT vs. MDMA/CPT
Plac < MDMA
L Inferior occipital (B18)	−20	−82	−8	0.004	L Inferior occipital (B18/19)	β3	−38	−38	−13	0.05 b
					L Prefrontal, L temporal, occipital	β3				0.006a
R Anterior cingulate (B32)	16	38	−4	0.001	L Ventrolateral prefrontal, R orbitofrontal, R anterior temporal, R dorsomedial prefrontal, anterior cingulate	α2				0.01a
R Medial frontal (B10)	8	62	0	0.02
L Fusiform gyrus	−44	−8	−24	0.02
Plac > MDMA
R paracentral lobule (B31)	2	−20	44	0.001	Temporal, occipital, central frontal, cingulate	α2				0.01a
Medial frontal (B6)	0	−8	52	0.001	L Posterior superior temporal (B39)	α2	−52	−60	29	0.05b
R Anterior cingulate (B24)	4	−2	44	0.001
L Anterior superior temporal (B22)	−50	−2	4	0.001
R Anterior superior temporal (B22)	52	0	4	0.001
Placebo/control task vs. Placebo/CPT
Control < CPT
L Orbitofrontal (B11)	−40	36	−22	0.001	R Inferior parietal (B40)	Δ	60	−46	43	0.05b
L Dorsoventral prefrontal (B10)	−28	62	−6	0.001	R Inferior parietal (B40)	Δ				0.012a
L Superior occipital (B19)	−30	−82	24	0.03	L Medial temporal (B21)	θ	−59	−4	−20	0.05b
					Whole brain, except L fusiform, L temporo‐occipital	θ				0.002a
L Occipital (B17/18)	−2	−90	2	0.04	Temporal, frontal	β1				0.001a
L Pre‐/postcentral	−44	−22	62	0.05	R Prefrontal, central frontal, cingulate, R temporal, L inferior temporal	β2				0.031a
					R Insula	β3	39	−11	1	0.05b
					Medial prefrontal, R temporal, R insula, posterior cingulate	β3				0.01a
Control > CPT
L Medial frontal (B11)	−22	36	−8	0.002	L Precuneus, L fusiform	θ				0.002a
L Inferior frontal (B9)	−32	18	28	0.001	Posterior cingulate, occipital	β1				0.001a
L Medial front (B46)	−32	18	18	0.001	L Occipital	β2				0.031 a
R Inferior frontal (B45)	56	16	6	0.001
R Frontal (B8)	18	14	42	0.004
R Precentral B44	52	12	12	0.004
R Anterior cingulate (B24)	16	6	44	0.004
R Medidal frontal (B6)	12	−2	58	0.001
L Insula (B13)	−34	22	8	0.001
R Anterior superior temporal (B22)	58	10	−2	0.001
MDMA/control task vs. MDMA/CPT
Control < CPT					(no significant changes)
R Dorsomedial prefrontal (B10)	14	68	8	0.05
L Anterior cingulate (B32)	−14	30	18	0.05
L Superior frontal (B9)	−14	46	34	0.05
L Medial occipital (B18/19)	−30	−86	10	0.001
Control > CPT					(no significant changes)
R temporal pole (B36)	26	−6	−32	0.001
R Medial temporal (B39)	46	−72	14	0.001
R Transveral temporal (B41)	48	−26	14	0.007
R Superior temporal (B22)	54	−24	2	0.007
R Insula (B13)	44	−26	22	0.007

^aCluster statistics

^bvoxel statistics (see Methods section).

Areas in boldface within sections indicate changes in PET and LORETA in corresponding brain areas of similar size, either in uniform or opposite direction. Note that Talairach coordinates cannot be given for LORETA results based on cluster statistics.