Table II.

Significant activations during the evaluation of unpleasant arousing words compared to neutral words*

Brain regions (BA)	Number of voxels in cluster	Talairach coordinates of local maximuma			Z score of local maximum
		X	Y	Z
Midline cortical activations
Anterior
L. Subgenual anterior cingulate (24)	31	−7	24	0	6.74
B. Orbital frontal (11, 10)	9	0	55	−14	3.86
Posterior
R. Posterior cingulate (30)	10	14	−38	7	4.92
L. Precentral (4)	7	−4	−34	62	4.33
L. Posterior cingulate (31)	14	−7	−21	38	4.21
L. mid cingulate (24)		−7	−7	41	3.75
L. Posterior cingulate (23)	6	−7	−55	24	3.97
Left hemisphere cortical activations
L. Inferior frontal (45, 47)	35	−55	31	3	5.00
L. Superior frontal (9)	16	−21	55	38	4.73
L. Superior temporal sulcus (21, 22)	22	−48	0	−17	4.65
L. Inferior and middle temporal (20, 21)	23	−58	−24	−14	4.05
L. Middle frontal (9)	6	−38	24	24	4.02
L. Middle frontal (10)	7	−31	52	3	3.98
Right hemisphere cortical activations
R. Auditory cortex (41, 42)	9	45	−31	17	5.03
R. Planum temporale and insula	15	48	−10	0	4.66
R. Fusiform (20)	6	38	−17	−28	4.37
R. Inferior frontal operculum/Insula	7	34	7	17	3.90
R. Middle temporal (21)	5	48	0	−28	3.83
Subcortical/cerebellar activations
L. Tail of caudate	28	−17	−28	21	5.83
R. Thalamus	7	21	−21	3	5.29
Midline cerebellum	35	0	−48	−24	5.00
L. Thalamus and septum	83	−10	−7	7	4.66
L. Parahippocampal		−17	−45	−3	4.28
L. Basal forebrain		−10	−3	−7	4.16
R. Caudate		10	3	10	4.12
R. Cerebellum	5	58	−55	−24	4.10
L. Cerebellum	28	−24	−58	−21	4.05
R. Amygdala	11	24	−7	−7	3.82

^*Brain regions containing clusters significantly more activated during evaluation of unpleasant words than neutral words. A cluster is considered activated if it contains ≥ 5 contiguous suprathreshold voxels (voxel threshold = Z ≥ 2.57 (P ≤ 0.005), cluster threshold = P ≤ 0.001) and contains at least one local maximum voxel for which Z ≥ 3.73 (P ≤ 0. 0001). Additional regions with local maxima within the same cluster are indented following the strongest local maximum for that cluster. L = left, R = right, B = bilateral; BA = Brodmann's Area in the region of observed activation.

^aHighest local maximum in each region.