Table 3. Clinical and laboratory characterization of all couples obtaining assisted reproductive technology and preimplantation genetic testing for beta thalassemia/hemoglobin E disease in this study.

ID	Maternal Age (years)	Paternal Age (years)	Maternal HBB Mutation	Paternal HBB Mutation	No. of Cycle	PGT-A Choice	Outcome
001	35	33	c.126_129delCTTT	c.79G>A	1	NGSa	Successful pregnancy with live birth of a male baby
002	33	33	c.79G>A	c.52A>T	2	NGS	Successful pregnancy with live birth of female monozygotic twins
003	35	36	c.79G>A	c.52A>T	1	NGS	Successful pregnancy with first trimester miscarriage
004	36	37	c.316-197C>T	c.79G>A	1	NGS	Failed implantation
005	36	36	c.79G>A	c.2T>G	4	NGS	Failed implantation
006	35	37	c.92+5 G>C	c.79G>A	1	NGS	Successful pregnancy with live birth of a male baby
007	41	44	c.79G>A	c.316-197C>T	2	NGS	No embryos suitable for transfer
008	37	37	c.79G>A	c.126_129delCTTT	2	aCGHb	Successful pregnancy with live birth of a male baby
009	37	39	c.316-197C>T	c.79G>A	1	aCGH	Successful pregnancy with live birth of a female baby
010	38	39	c.316-197C>T	c.79G>A	1	aCGH	Failed implantation
011	32	36	c.79G>A	Deletion	1	aCGH	Successful pregnancy with live birth of male monozygotic twins
012	38	33	c.79G>A	c.126_129delCTTT	1	aCGH	No embryos suitable for transfer
013	26	34	c.316-197C>T	c.79G>A	1	NGS	No embryos suitable for transfer
014	33	37	c.52A>T	c.79G>A	1	NGS	Successful pregnancy with live birth of a female baby
015	31	32	c.79G>A	c.52A>T	2	NGS	Successful pregnancy with live birth of a female baby

^aNGS = next-generation sequencing;

^baCGH = array comparative genomic hybridization