Fig 4. Median-joining networks of Plasmodium knowlesi MSP4 nucleotide haplotypes from Malaysia.

The genealogical haplotype network shows the relationships among the 24 haplotypes present in the 36 nucleotide sequences obtained from clinical isolates of Sarawak, Malaysian Borneo and laboratory adapted strains. Each distinct haplotype has been designated a number (H_n). Circle sizes represent the frequencies of the corresponding haplotype (the number is indicated for those that were observed >1×). Distances between nodes are arbitrary. The small red circles are median vectors (marked mv1) randomly generated by the software while constructing the network.