Table 1.
Subject Characteristics
| cGVHD Subjects (n=8) | Subject Number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | Summary* | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Demographics & | Age | 55 | 52 | 40 | 28 | 72 | 59 | 47 | 47 | 50 [45 - 56] | ||
| Race | C | C | C | C | C | C | C | C | 100% Caucasian | |||
| Gender | M | M | M | F | M | M | M | F | 25% Female | |||
| BMI | 24 | 24 | 27 | 14 | 32 | 17 | 23 | 34 | 24 [21-28] | |||
| Disease Characteristics# | Disease Histology | AL | MD | MD | MD | AL | AL | LD | AL | 50% AL 38% MD 12% LD 0% Other |
||
| Transplant Characteristics$ | Transplant Source | BM | PB | PB | PB | PB | PB | PB | BM | 75% PB 0% CB 25% BM |
||
| cGVHD Characteristics at Study Entry | NIH Score BSA Involvement | >50% | >50% | 19 - 50% | >50% | 19 - 50% | >50% | 1-18% | 19 - 50% | 1% No BSA involved 12% 1-18%BSA 38% 19-50%BSA 50% >50%BSA |
||
| NIH Score Skin Feature% | DS | DS | DS | DS | DS | DS | DS | DS | 0% No sclerotic
features 0% SS 100% DS |
|||
| Myoton Stiffness measurements by Sites (N/m)^ | Shin L | 878 | 1012 | 631 | 1318 | 892 | 1123 | 1621 | 1853 | 1067 [888 - 1394] | ||
| Shin R | 726 | 1555 | 544 | 1050 | 696 | 1126 | 1129 | 1924 | 1088 [718 - 1235] | |||
| Dorsal Forearm L | 674 | 436 | 512 | 1438 | 426 | 400 | 758 | 800 | 593 [433 - 769] | |||
| Dorsal Forearm R | 898 | 451 | 593 | 1140 | 439 | 388 | 781 | 1247 | 687 [448 - 959] | |||
| Upper Arm L | 488 | 330 | 297 | 462 | 493 | 530 | 529 | 337 | 475 [336 - 502] | |||
| Upper Arm R | 412 | 331 | 368 | 415 | 514 | 581 | 468 | 351 | 414 [363 - 479] | |||
| Shoulder L | 399 | 790 | 480 | 491 | 598 | 1093 | 725 | 346 | 544 [460 - 741] | |||
| Shoulder R | 471 | 1191 | 627 | 798 | 555 | 591 | 938 | 397 | 609 [534 - 833] | |||
| Chest L | 456 | 332 | 362 | 391 | 649 | 1088 | 350 | - | 391 [356 - 552] | |||
| Chest R | 361 | 353 | 318 | 1479 | 484 | 1348 | 334 | - | 361 [344 - 916] | |||
| Abdomen L | 312 | 274 | 179 | 152 | 261 | 380 | 258 | 215 | 260 [206 - 284] | |||
| Abdomen R | 381 | 287 | 194 | 131 | 253 | 402 | 275 | 239 | 264 [228 - 310] | |||
| Calf L | 878 | 1084 | 383 | 867 | 878 | 1210 | 971 | 808 | 878 [852 - 999] | |||
| Calf R | 754 | 1769 | 390 | 820 | 657 | 1222 | 967 | 782 | 801 [729 - 1031] | |||
| Upper Back L | - | 491 | 682 | 1388 | 677 | 1574 | 700 | - | 691 [678 - 1216] | |||
| Upper Back R | - | 547 | 548 | 918 | 754 | 958 | 653 | - | 704 [575 - 877] | |||
| Lower Back L | - | 307 | 563 | 261 | - | 448 | 328 | 228 | 318 [273 - 418] | |||
| Lower Back R | - | 287 | 457 | 516 | - | 457 | 336 | 219 | 396 [299 - 457] | |||
| Control Subjects (n=10) | Subject Number | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | Summary* |
| Demographics& | Age | 66 | 68 | 28 | 49 | 23 | 28 | 35 | 25 | 26 | 22 | 28 [25-46] |
| Race | C | C | AA | A | C | A | A | AA | C | A | 40% Calucasian | |
| Gender | M | M | M | F | M | F | M | M | M | F | 30% Female | |
| BMI | 31 | 24 | 29 | 22 | 22 | 18 | 25 | 22 | 29 | 19 | 23 [22-28] | |
| Myoton Stiffness measurements by Sites (N/m) | Shin L | 639 | 660 | 494 | 524 | 525 | 652 | 541 | 1102 | 686 | 627 | 632 [529-658] |
| Shin R | 759 | 627 | 604 | 468 | 550 | 623 | 645 | 998 | 916 | 598 | 625 [600-731] | |
| Dorsal Forearm L | 459 | 330 | 364 | 377 | 381 | 471 | 328 | 392 | 572 | 480 | 386 [367-468] | |
| Dorsal Forearm R | 438 | 420 | 350 | 403 | 439 | 502 | 401 | 363 | 566 | 390 | 411 [393-439] | |
| Upper Arm L | 444 | 338 | 285 | 280 | 239 | 328 | 326 | 381 | 367 | 480 | 333 [295-377] | |
| Upper Arm R | 429 | 399 | 301 | 327 | 309 | 359 | 288 | 366 | 315 | 375 | 343 [310-372] | |
| Shoulder L | 586 | 520 | 404 | 1127 | 179 | 364 | 366 | 329 | 397 | 375 | 386 [364-491] | |
| Shoulder R | 540 | 457 | 347 | 834 | 329 | 309 | 326 | 326 | 279 | 249 | 328 [313-429] | |
| Chest L | 419 | 470 | 322 | 303 | 243 | 314 | 192 | 268 | 206 | 436 | 309 [249-395] | |
| Chest R | 399 | 538 | 277 | 343 | 282 | 327 | 217 | 314 | 237 | 342 | 320 [278-342] | |
| Abdomen L | 234 | 351 | 159 | 194 | 163 | 242 | 202 | 189 | 202 | 296 | 202 [190-240] | |
| Abdomen R | 234 | 332 | 169 | 169 | 187 | 241 | 193 | 191 | 199 | 257 | 196 [188-239] | |
| Calf L | 483 | 574 | 375 | 384 | 398 | 328 | 372 | 412 | 637 | 326 | 391 [372-465] | |
| Calf R | 561 | 728 | 425 | 411 | 388 | 332 | 314 | 363 | 673 | 253 | 400 [340-527] | |
| Upper Back L | 463 | 684 | 490 | 416 | 359 | 394 | 359 | 526 | 329 | 258 | 405 [359-483] | |
| Upper Back R | 559 | 692 | 496 | 566 | 428 | 478 | 389 | 414 | 396 | 271 | 453 [401-543] | |
| Lower Back L | 409 | 362 | 249 | 244 | 158 | 195 | 243 | 279 | 214 | 193 | 243 [200-271] | |
| Lower Back R | 311 | 271 | 262 | 292 | 159 | 206 | 236 | 197 | 199 | 183 | 221 [198-269] | |
*
Values are shown as Median [IQR] for continuous variables and n (%) for categorical variables.
&
Demographics: C: Caucasian, , A: Asian, AA: African American, M: Male, F: Female
#
Disease characteristics: AL: Acute Leukemia, MD: Myeloid Disorder (Multiple Myeloma was included in lymphoid disorders), LD: Lymphoid Disorder
$
Transplant Characteristics: PB: Peripheral Blood, CB: Core Blood, BM: Bone Marrow
%
NIH Score Skin Feature: SS: Superficial sclerotic feature, DS: Deep and other sclerotic feature
-
Only 7 cGVHD patients were measured on the chest and 6 were measured on upper and lower back for patient comfort considerations.
^
Sites affected with sclerotic cGVHD are in bold