Table 6.
All-cause and lung cancer-specific mortality after lung cancer diagnosis in lung recipients compared with other lung cancer patients in the general population
| Model | Total lung cancer cases, n | Deaths, n (%) | Unadjusted HR (95% CI) | Lung cancer cases with treatment information, n § | Deaths, n (%)§ | Adjusted HR (95% CI) §|| |
|---|---|---|---|---|---|---|
| All-cause mortality* | ||||||
| All lung cancer | ||||||
| Lung recipients | 121 | 113 (94%) | 1.41 (1.17–1.69) | 84 | 78 (93%) | 1.90 (1.52–2.37) |
| Other patients | 1,168,149 | 1,026,848 (88%) | 1.0 (Ref) | 686,792 | 611,194 (89%) | 1.0 (Ref) |
| NSCLC | ||||||
| Lung recipients | 111 | 103 (93%) | 1.39 (1.15–1.69) | 76 | 70 (92%) | 1.84 (1.46–2.33) |
| Other patients | 983,939 | 860,563 (88%) | 579,440 | 513,240 (89%) | ||
| NSCLC curative treatment† | ||||||
| Lung recipients | 27 | 23 (85%) | 1.79 (1.20–2.69) | 27 | 23 (85%) | 2.18 (1.54–3.10) |
| Other patients | 190,629 | 140,887 (74%) | 1.0 (Ref) | 190,629 | 140,887 (74%) | 1.0 (Ref) |
| Lung cancer-specific mortality‡ | ||||||
| All lung cancer | 106 | 60 (57%) | 1.32 (1.03–1.69) | 1.67 (1.28–2.18) | ||
| Lung recipients | 947,125 | 555,592 (59%) | 1.0 (Ref) | 84 | 54 (64%) | 1.0 (Ref) |
| Other patients | 686,792 | 485,683 (71%) | ||||
| NSCLC | ||||||
| Lung recipients | 96 | 53 (55%) | 1.28 (0.98–1.67) | 76 | 48 (63%) | 1.62 (1.22–2.15) |
| Other patients | 795,129 | 459,592 (58%) | 1.0 (Ref) | 579,440 | 403,223 (70%) | 1.0 (Ref) |
| NSCLC curative treatment† | ||||||
| Lung recipients | 27 | 11 (41%) | 1.15 (0.64–2.08) | 27 | 11 (41%) | 1.83 (1.15–2.90) |
| Other patients | 190,629 | 96,294 (51%) | 1.0 (Ref) | 190,629 | 96,294 (51%) | 1.0 (Ref) |
Analyses of all-cause mortality included all registry areas that provide information on vital status: California, Colorado, Connecticut, Georgia, Hawaii, Iowa, Illinois, Kentucky, New Jersey, New York, Seattle-Puget Sound region, Texas, Utah
Analysis was restricted to patients with NSCLC with local or regional stage who underwent surgery and/or radiation as treatment. This analysis includes the following 8 registries that provided information on cancer treatment: California, Colorado, Connecticut, Georgia, Iowa, Kentucky (cases diagnosed in 2001 onward), New Jersey, Texas (2003 onward).
Analysis was restricted to the following registries that provided the cause of death information: California, Colorado, Connecticut, Georgia, Iowa, Illinois, Kentucky, New Jersey, Seattle, and Texas.
Analysis was restricted to the following 8 registries that provided information on cancer treatment: California, Colorado, Connecticut, Georgia, Iowa, Kentucky (cancers diagnosed in 2001 onward), New Jersey, Texas (2003 onward).
Models were adjusted for age at cancer diagnosis, sex, race, year of cancer diagnosis, cancer stage and treatment.
NSCLC=non-small cell lung cancer, HR=hazard ratio